資源描述：
《血色素沉著癥的MRI診斷》由會員上傳分享，免費在線閱讀，更多相關內容在行業(yè)資料-天天文庫。
1、醫(yī)學影像學雜志2010年第20卷第7期JMedImagingVol.20No.72010血色素沉著癥的MRI診斷郭學軍,王成林,劉鵬程,石橋,向先俊,單慧明(北京大學深圳醫(yī)院影像中心廣東深圳518036)摘要目的:探討血色素沉著癥的MRI表現(xiàn),分析其MRI特征,對病變組織的鐵質沉積作初步定量分析,同時評價MRI在血色素沉著癥的診斷中的價值。方法:對19例血色素沉著癥患者及20例對照組測量其T2WI上肝、脾及豎脊肌的信號強度,分別計算肝臟、脾臟與豎脊肌的信號強度比值,計算其信號比值下降程度。結果:19例血色素沉著癥病例中,MRI檢查在各種不同序列中均可見不
2、同程度組織信號強度減低,T1WI和T2WI亦都可顯示組織信號減低,以T2WI顯示更為明顯,其中以GRE序列尤為敏感。19例中,肝、脾信號都明顯減低者6例,單純肝臟信號減低者8例,5例脾臟信號減低而肝臟信號減低不明顯,未見1例胰腺信號明顯減低病例。結論:MRI對血色素沉著癥的診斷具有高度的敏感性和特異性,結合實驗室檢查,可取代組織活檢的金標準地位,對血色素沉著癥的早期診斷和早期治療具有重要的臨床意義。關鍵詞血色素沉著癥;磁共振成像中圖分類號:R596;R445.2文獻標識碼:A文章編號:1006-9011(2010)07-1034-04MRIdiagnos
3、isofhemochromatosisGUOXuejun,WANGChenlin,LIUPengcheng,SHIQiao,XIANGXianjun,SHANHuimingDepartmentofRadiology,PekingUniversityShenzhenHospital,Shenzhen518036,P.R.ChinaAbstractObjective:ToinvestigateMRImanifestationsandcharacteristicsofhemochromatosis,tomakeapreliminaryquantitativeanal
4、ysisofthelevelofreducedsignal,aswellastoevaluatethevalueofMRIindiagnosisofhemochromatosis.Methods:Thesignalintensitiesofliver,spleenandspinalmuscularerectionweremeasuredon19caseswithhemochromatosisand20casesincontrolgroup,andthesignalintensityratioandthelevelofreducedsignalratiowerecalcula
5、tedseparately.Results:Of19caseswithhemochromatosis,eachofdifferentMRIsequencescoulddisplayreducedsignalintensityofvaryingseverityinliverandspleen.T1WIandT2WIalsoshowedreducedsignalintensityofliverandspleen,obviouslyonT2WI,andmoresensitiveespeciallyonGREsequence.Of19cases,thesignalintensityr
6、educedobviouslyin6casesbothinliverandspleen,8casesonlyinliver,5casesinspleenbutnoobviouslyinliver,nocasesinpancreas.Conclusion:MRIhasahighdegreeofsensitivityandspecificityforthediagnosisofhemochromatosis.Bycombiningwithlaboratorytests,MRIcanreplacethegoldstandardstatusofbiopsy.Ithasveryi
7、mportantclinicalsignificanceforearlydiagnosisandtreatmentofhemochromatosis.KeywordsHemochromatosis;Magneticresonanceimaging血色素沉著癥是由于鐵質過多沉積在人體組織性12例,女性7例,年齡17~81歲,平均年齡46.3內所致。MRI對血色素沉著癥的診斷有較高的敏感歲。19例中,僅有1例為MRI檢查前即有明確血色性和特異性,但國內目前有關本病的系統(tǒng)報道不多。素沉著癥病史復查病
