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1、HistoryofResearchonTumorAngiogenesisDomenicoRibattiHistoryofResearchonTumorAngiogenesis123Prof.DomenicoRibattiUniversitadiBari`PoliclinicoDipartimentodiAnatomiaUmanaeIstologiaBariItalyribatti@anatomia.uniba.itISBN978-1-4020-9559-7e-ISBN978-1-4020-9563-4DOI10.1007/978-1
2、-4020-9563-4LibraryofCongressControlNumber:2008940585cSpringerScience+BusinessMediaB.V.2009Nopartofthisworkmaybereproduced,storedinaretrievalsystem,ortransmittedinanyformorbyanymeans,electronic,mechanical,photocopying,micro?lming,recordingorotherwise,withoutwrittenper
3、missionfromthePublisher,withtheexceptionofanymaterialsuppliedspeci?callyforthepurposeofbeingenteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthework.Printedonacid-freepaper987654321springer.comDedicatedtothememoryofJudahFolkman,apioneerinthestudyoftum
4、orangiogenesisContentsChapter1.........................................................11.1EarlyEvidenceoftheVascularPhaseandItsImportanceinTumorGrowth..........................................11.2EarlyEvidenceofTumorCellsReleasingSpeci?cGrowthFactorforBloodVessels....
5、.....................................21.3TumorsinIsolatedPerfusedOrgans:AbsenceofAngiogenesis...51.3.1Hypothesis:TumorGrowthIsAngiogenesis-Dependent..61.3.2EvidencethatTumorsAreAngiogenesis-Dependent.....61.4TheAvascularandVascularPhasesofSolidTumorGrowth......91.4.1Fi
6、rstEvidenceoftheExistenceoftheAvascularandVascularPhasesofSolidTumorGrowth..............91.4.2TheSigni?canceofAngiogenesisinHematologicalMalignancies.....................................101.4.3Non-Angiogenesis-DependentPathwaysforTumorGrowth:VascularCooptionandVasculog
7、enicMimicry..15Chapter2.........................................................192.1IsolationoftheFirstAngiogenicTumorFactor.................192.2TheDiscoveryofBasicFibroblastGrowthFactor/FibroblastGrowthFactor-2..........................................202.2.1FGF-2Re
8、ceptorsandFGF-2Interactions..............212.2.2TheRoleofFGF-2inTumorGrowthandVascularization222.3TheDiscoveryofVascu
