To exploit the tumor microenvironment. Passive and active tumor targeting of

To exploit the tumor microenvironment. Passive and active tumor targeting of

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時(shí)間：2019-08-12

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1、JournalofControlledRelease148(2010)135–146ContentslistsavailableatScienceDirectJournalofControlledReleasejournalhomepage:www.elsevier.com/locate/jconrelReviewToexploitthetumormicroenvironment:Passiveandactivetumortargetingofnanocarriersforanti-cancerdrugdeliver

2、yaba,?FabienneDanhier,OlivierFeron,VéroniquePréataUniversitéCatholiquedeLouvain,LouvainDrugResearchInstitute,UnitofPharmaceutics,UCL-FARG7320,AvenueE.Mounier,B-1200,Brussels,BelgiumbUniversitéCatholiquedeLouvain,PoleofPharmacologyandTherapeutics,InstituteofExpe

3、rimentalandClinicalResearch,UCL-FATH5349,AvenueE.Mounier,B-1200,Brussels,BelgiumarticleinfoabstractArticlehistory:Becauseoftheparticularcharacteristicsofthetumormicroenvironmentandtumorangiogenesis,itisReceived31May2010possibletodesigndrugdeliverysystemsthatspe

4、ci?callytargetanti-cancerdrugstotumors.MostoftheAccepted10August2010conventionalchemotherapeuticagentshavepoorpharmacokineticspro?lesandaredistributednon-Availableonline24August2010speci?callyinthebodyleadingtosystemictoxicityassociatedwithserioussideeffects.Th

5、erefore,thedevelopmentofdrugdeliverysystemsabletotargetthetumorsiteisbecomingarealchallengethatisKeywords:currentlyaddressed.NanomedicinecanreachtumorpassivelythroughtheleakyvasculaturesurroundingActivetargetingPassivetargetingthetumorsbytheEnhancedPermeability

6、andRetentioneffectwhereasligandsgraftedatthesurfaceofEnhancedPermeabilityandRetentioneffectnanocarriersallowactivetargetingbybindingtothereceptorsoverexpressedbycancercellsorangiogenicNanocarriersendothelialcells.Thisreviewisdividedintotwoparts:the?rstonedescri

7、besthetumormicroenvironmentandthesecondonefocusesontheexploitationandtheunderstandingofthesecharacteristicstodesignnewdrugdeliverysystemstargetingthetumor.Deliveryofconventionalchemotherapeuticanti-cancerdrugsismainlydiscussed.?2010ElsevierB.V.Allrightsreserved

8、.Contents1.Introduction..............................................................1352.Tumormicroenvironment.......................................................1362.1.

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