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1、VirtualExperimentRespiratoryRegulationDr.LLWangEmail:wanglinlin@zju.edu.cnRm608,BlockB,ResearchBuilding,SchoolofMedicine,ZijingangCampus[Purpose]￠Toinvestigatetheeffectsofcarbondioxide,hypoxia,deadspace,[H+]andvagusnervestimulationonrespiratorymovements.[Principle]￠The
2、rhythmicrespiratorymovementswhichcausethepulmonaryventilationarecontrolledbytherespiratorycenter.￠Respiratoryneuronsinthemedullacontrolinspirationandexpiration￠Neuronsintheponsinfluencetherateanddepthofventilation￠Rhythmicpatternofbreathingarisesfromanetworkofspontaneo
3、uslydischargingneurons￠Ventilationissubjecttomodulationbychemicalfactorsandbyhigherbraincenters￠Manyfactorsaffecttherespiratorycenterthroughreflexmechanismstoregulatetheamplitudeandfrequencyofventilation.BasicRespiratoryCenter￠BrainStem￠Medullaoblongata￠PonsCentralChem
4、oreceptorChemoreceptorNeuronsNeartheventralsurfaceofthemedullaPeripheralChemoreceptors￠Aorticandcarotidbody￠responsetochangesinPO,PCOandpH22EffectofArterialPCOonalveolarventilation2￠mostly(80%)mediatedbythecentralchemoreceptor￠20%oftheresponseisduetoperipheralchemorece
5、ptorstimulationEffectofArterial[H+]onalveolarventilation￠mediatedbytheperipheralchemoreceptorstimulationEffectofArterialPOonalveolarventilation2￠mediatedbytheperipheralchemoreceptorstimulation[Experimentalobject]￠Rabbit[VirtualExperimentProcedure]￠VirtualExperimentProc
6、edurewillbedemonstrated.￠Openthevirtualexperimentwindowofrespiratoryregulation￠Movethemousetoscalpelicon.Clicktheleftkeyofmousetomovescalpeltotheneckareaoftherabbittoactivatetwovideowindows.(Fig.4-2).Oneisabouttheprocedureofseparatingthevagusnervesbesidethetrachea.Theo
7、therisaboutthemethodofendotrachealintubation.￠Clickthe“measure”buttontorecordthecurveofrespiratorymovements.￠Measurethechangesofamplitudeandfrequencyofrespiratorymovements.￠Experimentitems￠Normalcondition￠CO2￠Hypoxia(N2)￠Deadspace(latextube(40cmlength)+￠Highconcentatio
8、nof[H]￠VagusnervesResultsTable4-1:EffectsofCO,hypoxia,deadspace,[H+]andvagusnerveson2therespiratorymovementinrabbit.F
