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《ngf及其受體p75與肝素酶在口腔腺樣囊性癌嗜神經(jīng)侵襲中的表達(dá)及相關(guān)性分析》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、口腔醫(yī)學(xué)研究2010年2月第26卷第1期35NGF及其受體P75與肝素酶在口腔腺樣囊性癌嗜神經(jīng)侵襲中的表達(dá)及相關(guān)性分析*駱樹瑜張玉茹李宏捷朱曉紅李秋芝(天津醫(yī)科大學(xué)口腔醫(yī)院病理科天津300070)[摘要]目的:探討腺樣囊性癌(adenoidcysticcarcinoma,ACC)組織中肝素酶(heparanase,HPA)和神經(jīng)生長因子(nervegrowthfactor,NGF)及其受體P75的表達(dá)和相互作用,以及與ACC嗜神經(jīng)侵襲之間的關(guān)系。方法:應(yīng)用免疫組化SP法檢測42例ACC組織中HPA、NGF和P75的表達(dá),并對他們在不同病理類型和組織學(xué)部位的表達(dá)進(jìn)行統(tǒng)計(jì)學(xué)分析。
2、結(jié)果:NGF和P75在嗜神經(jīng)(PNI)組和非嗜神經(jīng)(NPNI)組的表達(dá)有統(tǒng)計(jì)學(xué)差異(P<0.05),兩者呈正相關(guān)(r=0.429,P<0.05)。嗜神經(jīng)組HPA和P75的表達(dá)正相關(guān)(r=0.558,P<0.05)。P75在神經(jīng)周組織和遠(yuǎn)離神經(jīng)部位的表達(dá)有顯著性差異(P<0.05),NGF在神經(jīng)組織和遠(yuǎn)離神經(jīng)處的表達(dá)無明顯差異。結(jié)論:在ACC的神經(jīng)浸潤中,NGF及其受體P75扮演著重要角色,但并非唯一因素,NGF可以通過和受體p75結(jié)合可以提高HPA的表達(dá)率和生物活性,進(jìn)而促進(jìn)ACC對神經(jīng)組織的浸潤。[關(guān)鍵詞]神經(jīng)生長因子及其受體肝素酶腺樣囊性癌嗜神經(jīng)侵襲[中圖分類號(hào)]R739.8
3、[文獻(xiàn)標(biāo)識(shí)碼]A[文章編號(hào)]16717651(2010)01003504ExpressionandCorrelationbetweenNerveGrowthFactorandItsReceptorp75andHeparanaseinPerineuralInvasionofAdenoidCysticCarcinoma.LUOShu-yu,ZHANGYu-ru,LIHong-jie,etal.DepartmentofOralPathology,CollegeofStomatology,TianjinMedicalUniversity,Tianjin300070[Abstract
4、]Objective:ToinvestigatemechanismofinteractionofNerveGrowthFactor(NGF),itsReceptorp75andheparanase(HPA),aswellastherelationshipsbetweenadenoidcysticcarcinoma(ACC)andperineuralinvasionbydetectingtheirexpressionsinACC.Methods:TheexpressionsofNGF,p75andHPAweredetectedbySPimmunohistochemistrymethods,
5、andtheirexpressionlevelsindifferentpathologicaltypesandhistologicalregionswereanalyzed.Results:ThedifferenceofpositiveexpressionofNGFandP75betweenperineuralinvasion(PNI)groupandnon-perineuralinvasion(NPNI)groupwassignificant(P<0.05).Thepositiveexpressionsofp75andHPAwerecloselycorrelatedPNIgroup(r=0
6、.558,P<0.05).Theexpressionlevelsofp75infasciculushadsignificantdeviationcomparedwiththatindistanttumortissues(P<0.05).Conclusion:NGFandP75playedimportantrolesinthePNIofACC,butnotastheonlyfactors.ThecombinationofNGFandp75couldenhancetheexpressionandbioactivityofHPA,whichwouldopenupmorespacefortumorc
7、ellsandenhancetheinvasionintonervetissues.[Keywords]NervegrowthfactorandreceptorHeparanaseAdenoidcysticcarcinomaPerineuralinvasionACC嗜神經(jīng)侵襲(perineuralinvasion,PNI)的到眾多學(xué)者的關(guān)注,但對兩者與基底膜降解酶HPA出現(xiàn)不僅是預(yù)后不良的一個(gè)指標(biāo)
