臭氧治療外陰陰道假絲酵母菌病的臨床研究

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1、臭氧治療外陰陰道假絲酵母菌病的臨床研究沈慧敏楊越波黃敏李小毛劉曉霞李卉張宇【摘要】目的評(píng)價(jià)臭氧治療外陰陰道假絲酵母菌病的有效性和安全性。方法采用隨機(jī)對(duì)照、開放設(shè)計(jì)，入選外陰陰道假絲酵母菌病患者72例，其中試驗(yàn)組36例接受臭氧治療，對(duì)照組36例接受達(dá)克寧栓治療，于治療前、治療結(jié)束后第3天觀察臨床癥狀及體征，并進(jìn)行陰道分泌物病原學(xué)檢查。結(jié)果治療結(jié)束后第3天，試驗(yàn)組和對(duì)照組的痊愈率分別為5&3%和61.1%，有效率分別為83.3%和8&9%,癥狀平均緩解時(shí)間分別為2.58d和2.36d,假絲酵母菌陰轉(zhuǎn)率分別為94.4%和100%。2組之間比較差異均無統(tǒng)計(jì)學(xué)意義(P>0.05)o72例病例中無不

2、良事件與嚴(yán)重不良事件發(fā)生。結(jié)論臭氧治療外陰陰道假絲酵母菌病安全、有效?！娟P(guān)鍵詞】臭氧;硝酸咪康哩栓汐卜陰陰道假絲酵母菌病AClinicalTrialofOzoneinTheTreatmentofVulvovaginalCandidiasisSHENHui-min,YANGYue-bo,HUANGakDepartmentofObstetricandGynecology,TheThirdAJJiliatedHospital,SUNYat-senUniversity,Guangzhou510630,China[Abstract]ObjectiveToevaluatetheefficacyan

3、dsafetyofozoneinthetreatmentofvulvovaginalcandidiasis.MethodsArandomized,controlled?openclinicaltrialincluding72casessufferedvulvovaginalcandi?diasiswasconducted,36casesintrialgroupweregivenozonetherapyand36casesincontrolgroupweregivenmiconazolenitratesuppositories.3daysaftertheendoftreatment,Co

4、mparedthechangeofclinicalsymptomsandsignstheresultofBVblueexaminationbetweentrialgroupandcontrolgroup.Results3daysaftertheendoftreatment,thecurerateswere5&3%intrialgroupand61.1%incontrolgroupTtheefficacyrateswere83.3%intrialgroupand88.9%incontrolgroup,theaverageperiodsofsymptomrelaxingwere2.58day

5、sintrialgroupand2.36daysincontrolgroup.Therewerenosignificantdifferencesbetweenthesetwogroups(P>0.05)?Theeradicatedratesofpathogenwere94.4%intrialgroupand100%incontrolgroup-Therewerenosignificantdifferencesbetweenthesetwogroupsineradicatedratesofpathogen(P>0.05).Therewerenoadverseventsandseverea

6、dverseeventshappenedinallthese72cases.ConclusionOzoneiseffectiveandsafeinthetreatmentofvulvovaginalcandidiasis.[Keywords]Ozone；Miconazolenitratesuppositories;Vulvovaginalcandidiasis1.1病例選擇我院婦產(chǎn)科門診外陰陰道假絲酵母菌病患外陰陰道假絲酵母菌病(vulvovaginalcandidiasis,VVC)也稱外陰陰道假絲酵母菌病，是由不同假絲酵母菌(主要是白念珠菌)感染所致的外陰陰道炎癥。為常見的婦女外陰陰

7、道炎癥。據(jù)報(bào)道，約75%的婦女一生中至少患過1次VVC,5%的患者可反復(fù)發(fā)作，給廣大婦女帶來了巨大的生理和心理上的痛苦[b2]o因此如何治療VVC—直是廣大臨床醫(yī)生和婦女最關(guān)心的冋題之臭氧是一種高效、快速的消毒滅菌劑，具有高效消毒、強(qiáng)氧化和催化的功能，應(yīng)用領(lǐng)域廣泛⑶，但應(yīng)用在治療婦女生殖道炎癥還是首次。本研究采用深圳市匯源田實(shí)業(yè)發(fā)展有限公司生產(chǎn)的臭氧婦科治療系統(tǒng)HYS-2000治療女性外陰陰道假絲酵母菌病,評(píng)價(jià)臭氧治療外陰陰道假絲酵