3、enter>LiHong,WangLiantangxPstyle=nTEXT-INDENT:24pxnalign=centei>DepartmentofPathology,CentralHospitalofRailway,Guangzhou510080?[Abstract]ObjectiveToassesstheclinicopathologicalfeaturesandhistogenesisofstromalcellsofheman~gioblastoma.MethodsFifty-eightcasesofh
4、emangioblastomawerestudiedbylightmicroscopyandexaminedbyim~munohistochemicalstaining.ResultsTheiragesrangedfrom20to71yearsold(average,38).Thetumorwaslocatedinthecerebellain49cases(84.5%);inmedullaoblongata,spinalcordandmeningesintherest(15.5%).Therewerecyctic
5、changesofthetumorin48cases(82.8%)?Histologically,the58casesofHBwerefurthercategorizedintothreesubtypes:typical(30cases),reticular(7cases)andcellular(21cases)?In58cases,thestromalcellswereposi~tiveforNSE,S-lOOprotein,butnegativeforEMA>CD34、GFAPandAAT.Conclusio
6、nHemangioblastomamostlyoccursincerebellaofadult,therearethreeessentialhistologiccategories;itsstromalcellshavevimentinexpresionandtheymaywellbeangiogenicmesenchymalcells.Keywordshemangioblastomastromalcellhistopathologyiinmunohistocheiiiistry血管母細(xì)胞瘤是屮樞神經(jīng)系統(tǒng)較特姝的
7、良性血管腫瘤,比較少見,其發(fā)生率占顱內(nèi)腫瘤的1.5%?2%,但占小腦及第IV腦室腫瘤的11.6%[1]o我們的資料中該腫瘤占顱內(nèi)腫瘤的1.8%,本組58例報(bào)告如下。1材料與方法1.1材料58例血管母細(xì)胞瘤來自中山大學(xué)病理學(xué)教研室及廣州鐵路中心醫(yī)院病理科,男38例,女20例,年齡20?71歲,平均年齡38歲。發(fā)生部位為左小腦半球21例。臨床表現(xiàn)有頭痛、頭暈、嘔吐46例,行走不穩(wěn)25例,視力下降、復(fù)視8例,四肢麻木6例,腰痛2例,舌肌抽搐1例,吞咽困難1例。其中3例為術(shù)后復(fù)發(fā)病例,復(fù)發(fā)時(shí)間分別為3?4年。1.2方法5
8、8例血管母細(xì)胞瘤均為手術(shù)后標(biāo)木,10%中性福爾馬林固定,常規(guī)石蠟包埋,HE染色,切片厚4?m。免疫組化染色采用S?P法,選用抗體包KVimentin(單抗)、CD34(單抗、NSE(多抗)、GFAP(多抗)、AAT(多抗)、S-100(多抗)、EMA(單抗),均為Dako公司產(chǎn)品。2結(jié)果2.1巨檢腫物均有淸楚的界限,最大為5cmX5cmX4cm,最小為2cmXlcmXlc