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1、糖耐量減低患者胰島素抵抗與血脂變化的臨床觀察［摘要］目的探討糖耐量減低(IGT)患者胰島素抵抗和血脂的相關(guān)性。方法選擇2011年1月?2013年1月來本院下屬5家社康就診的120例IGT患者作為實驗組，選収同時期120例糖耐量正常志愿者作為對照組,分別測定兩組入選者空腹胰島素(Fins)水平、餐后2h胰島索(2hlns)水平、三酰甘油(TG)、總膽固醇(TC)、高密度脂蛋白膽固醇(HDL-C).低密度脂蛋白膽固醇(LDL-C)、游離脂肪酸(FFA)等各項指標水平,并計算兩組入選者胰島素抵抗指數(shù)(H0MA-IR)、胰島素分泌指數(shù)(HOMA-B)以及葡萄糖處置指數(shù)(GDI)
2、等。結(jié)果實驗組TG、FFA、空腹血糖均顯著高于對照組，IIDL-C明顯低于對照組，差異均有統(tǒng)計學(xué)意義(P0.05)；實驗組H0MATR、FIns^2hIns水平顯著高于對照組，GDI顯著低于對照組,差異均冇統(tǒng)計學(xué)意義(P〈0?05)。結(jié)論IGT患者有明顯的胰島素抵抗以及高血脂癥狀，因此臨床中要注意防止出現(xiàn)高脂血癥。［關(guān)鍵詞］糖耐量減低；胰島素抵抗；血脂［中圖分類號］R587［文獻標識碼］B［文章編號］1674-4721(2013)11(c)-0187-02Clinicalobservationofinsulinresistanceandbloodlipidchanges
3、inpatientswithimpairedglucosetoleranceCHENYong-qingDepartmentofGeneralPractice,PeoplezsHospitalofYantianDistrictinShenzhenCityinGuangdongProvince,Shenzhen518081,China[Abstract]ObjectiveToexplorethecorrelationbetweeninsulinresistanceandbloodlipidinpatientswithimpairedglucosetolerance(IGT)
4、?Methods120patientswithIGTtreatedin5communityhealthservicecentersaffiliatedtoourhospitalfromJanuary2011toJanuary2013wereselectedasexperimentalgroup.Another120volunteerswithnornialglucosetoleranceinthesameperiodwerechosenascontrolgroup.Theindexeslikefastinginsulin(FTns)level,2hpostprandia
5、linsulin(2hIns)level,triglyceride(TG),totalcholesterol(TO),highdensitylipoproteincholesterol(HDL-C),lowdensitylipoproteincholesterol(LDL-C)andfreefattyacid(FFA)weretestedinbothgroupsinordertocalculatethehomeostasismodelassessmentofinsulinresistanee(HOMA-TR),homeostasismodelassessmentofBc
6、ellsecretion(HOMA-P)andglucosedisposalindex(GDI)?ResultsThelevelsofTG,FFA,andfastingblood-glucoseintheexperimentolgroupwereremarkablyhigherthanthoseofthecontrolgroup,whilethevalueofHDL-Cwasobviouslylowerthanthatofthecontrolgroupwithstatisticaldifferences(P0.05).ThelevelsofHOMA-IR,Finsand
7、2hInsintheexperimentalgroupwereobservablyhigherthanthoseofthecontrolgroup,buttheGDIwaslowerthanthatofthecontrolgroup,thedifferenceswerestatisticallysignificant（P〈O.05）?ConclusionDuetoobviousinsulinresistanceandhyperlipidemiainpatientswithIGT,thepreventionofitsoccurrencesh
