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1、糖耐量減低患者胰島素抵抗與血脂變化的臨床觀察［摘要］目的探討糖耐量減低（IGT）患者胰島索抵抗和血脂的相關(guān)性。方法選擇2011年1月?2013年1月來(lái)本院下屬5家社康就診的120例IGT患者作為實(shí)驗(yàn)組，選取同時(shí)期120例糖耐量正常志愿者作為對(duì)照組,分別測(cè)定兩組入選者空腹胰島索（Fins）水平、餐后2h胰島索（2hlns）水平、三酰甘油（TG）、總膽固醇（TC）、高密度脂蛋白膽固醇（HDL-C）、低密度脂蛋白膽固醇（LDL-C）、游離脂肪酸（FFA）等各項(xiàng)指標(biāo)水平，并計(jì)算兩組入選者胰島素抵抗指數(shù)（H0MA-TR）.胰島素分泌指數(shù)（HOMA-B）以及葡萄糖處置指
2、數(shù)（GDI）等。結(jié)果實(shí)驗(yàn)組TG、FFA.空腹血糖均顯著高于對(duì)照組，IIDL-C明顯低于對(duì)照組，差異均有統(tǒng)計(jì)學(xué)意義（P0.05）；實(shí)驗(yàn)組HOMA-IR、Fins、2hIns水平顯著高于對(duì)照組，GDI顯著低于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）o結(jié)論IGT患者有明顯的胰島素抵抗以及高血脂癥狀，因此臨床中要注意防止出現(xiàn)高脂血癥。［關(guān)鍵詞］糖耐量減低；胰島索抵抗；血脂［中圖分類號(hào)］R587［文獻(xiàn)標(biāo)識(shí)碼］B［文章編號(hào)］1674-4721（2013）11（c）-0187-02Clinicalobservationofinsulinresistanceandbloo
3、dlipidchangesinpatientswithimpairedglucosetoleranceCIIENYong-qingDepartmentofGeneralPractice,PeoplezsHospitalofYantianDistrictinShenzhenCityinGuangdongProvince,Shenzhen518081,China[Abstract]ObjectiveToexplorethecorrelationbetweeninsulinresistanceandblood1ipidinpatientswithimpairedg
4、lucosetolerance(IGT).Methods120patientswithIGTtreatedin5communityhea1thservicecentersaffiliatedtoourhospitalfromJanuary2011toJanuary2013wereselectedasexperimentalgroup.Another120volunteerswithnormalglucosetoleranceinthesameperiodwerechosenascontrolgroup.Theindexes1ikefastinginsulin
5、(FTns)level,2hpostprandialinsulin(2hIns)level,triglyceride(TG),totalcholesterol(TC),highdensitylipoproteincholesterol(HDL-C),lowdensitylipoproteincholesterol(LDL-C)andfreefattyacid(FFA)weretestedinbothgroupsinordertocalculatethehomeostasismodelassessmentofinsulinresistance(HOMA-TR)
6、,homeostasismodelassessmentofBcellsecretion(HOMA-13)andglucosedisposalindex(GDI)?ResultsThelevelsofTG,FFA,andfastingblood-glucoseintheexperimentalgroupwereremarkablyhigherthanthoseofthecontrolgroup,whilethevalueofHDL-Cwasobviouslylowerthanthatofthecontrolgroupwithstatisticaldiffere
7、nces(P0.05)?ThelevelsofHOMA-IR,Finsand2hInsintheexperimentalgroupwereobservablyhigherthanthoseofthecontrolgroup,buttheGDTwas1owerthanthatofthecontrolgroup,thedifferenceswerestatisticallysignificanl（P〈0.05）?ConclusionDuetoobviousinsulinresistanceandhyperlipidemiainpatientswithIGT,th
8、epreventionofitsoccurrence
