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1、目的:探討甲氨蝶吟(MTX)肌肉注射及中藥生化湯聯(lián)合治療植入性胎盤的療效。方法:將41例胎盤植入的患者隨機(jī)分為兩組,研究組19例,給TMTX治療,方法為50mg隔日肌內(nèi)注射3次,并于注射MTX后12?24h內(nèi)加用甲酰四氫葉酸(CF)解毒,同時(shí)每天給了中藥生化湯(加減)口服;對(duì)照組22例,僅采用口服中藥生化湯(加減)治療,兩組治療前血清P-HCG值、宮腔內(nèi)病灶面積大小均無(wú)明顯差異,兩組均定期復(fù)查B超和血清p-HCG水平直至正常。結(jié)果:經(jīng)治療1周及2周后復(fù)查,研究組血清p-HCG值均較前次檢查結(jié)果明顯下降(P<0.001),宮腔內(nèi)殘留胎盤組織面積也較前次檢查結(jié)果明顯縮小(P<0.
2、001),與同期對(duì)照組血清P-HCG值及宮腔內(nèi)殘留庭盤組織面積相比較,其差異亦有統(tǒng)計(jì)學(xué)意義(P<0.001),而研究組血清p-HCG水平降至正常時(shí)間亦較對(duì)照組明顯縮短(P<0.001)o結(jié)論:MTX肌內(nèi)注射聯(lián)合中藥生化湯治療胎盤植入,其效果較單純應(yīng)用中藥生化湯治療療效更佳,可以有效治療植入性胎盤,最大限度地保留子宮,保留生育功能?!娟P(guān)鍵詞】甲氨蝶吟;生化湯;植入性胎盤;血清P-HCG;產(chǎn)后出血ClinicalapplicationofmethotrexateconnectingbiochemistrysoupinplacentaimplantationLIMiao,XUXia
3、o-feng(ShilongBoaiHospitalofDongguanCity,Dongguan523320,China)Abstract:ObjectiveTostudytheeffectsofmethotrexateconnectingbiochemistrysoupforplacentaimplantation.MethodTotal41patientswithplacentaimplantationwererandomlydividedintotheresearchgroup(n=19)andthecontrolgroup(n=22).Subjectsofthere
4、searchgroupwereinjectedwith50mgmethotrexate(MTX)intomuscleeveryotherday.LeucovorininjectionwasusedtopreventharmfuleffectsofMTXin12~24hoursafterMTXinjectiomandbiochemistrysoupwastakenorallyeveryday.Controlsubjectswerejusttreatedwithbiochemistrysoup.Nodifferencesofserump-HCGlevelandareaofresi
5、duesofplacentawerefoundbetweenthetwogroupsbeforetreatment.ResultsAfteroneortwoweeks1treatment,serump-HCGleveldecreasedandwaslowerintheresearchgroupthanthecontrolgroup(P<0.001).Areaofresiduesofplacentasignificantlydecreasedintheresearchgroupthanthecontrolgroup(P<0.001).Meanwhile,thetimeofser
6、ump-HCGleveldecreasedtonormallevelwassignificantlyshorterintheresearchgroupthanthecontrolgroup(P<0.001).ConclusionMTXinjectionintomuscleconnectingbiochemistrysoupinplacentaimplantationcanretaintheuterustothegreatextent,alsothefertileability.KeyWords:Methotrexate;Biochemistrysoup;Placentaimp
7、lantation;p-HCG;Postpartumhemorrhage植入性胎盤是產(chǎn)科少見(jiàn)但較嚴(yán)重的并發(fā)癥,患者足月分娩或中期妊娠引產(chǎn)時(shí),在第三產(chǎn)程中,當(dāng)胎盤不能完全剝離時(shí),若處理不當(dāng),可發(fā)生產(chǎn)后大出血,嚴(yán)重時(shí)危及產(chǎn)婦生命。對(duì)出現(xiàn)產(chǎn)后大出血的患者,治療多以手術(shù)切除子宮為主,對(duì)于無(wú)活動(dòng)性出血或通過(guò)加強(qiáng)子宮收縮,局部壓迫止血后出血較少的患者,則多采取保守治療。目前植入性胎盤的保守治療包括:期待觀察治療、藥物治療、經(jīng)導(dǎo)管雙側(cè)子宮動(dòng)靜脈栓塞術(shù)等。本文采用甲氨蝶吟(MTX)肌內(nèi)注射及中藥生化湯聯(lián)合治療19例胎盤