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1、球后注射鼠神經(jīng)生長因子治療小兒皮質(zhì)盲臨床研究作者:陳霄,張敏作者單位:710024中國,西安,西安中醫(yī)腦病醫(yī)院【摘要】口的:觀察球后注射鼠神經(jīng)生長因子對小兒皮質(zhì)盲的療效,改善患兒預后。方法:2005-01/2009-10西安中醫(yī)腦病醫(yī)院治療患兒118例,隨機、單盲分為兩組,治療組(球后注射鼠神經(jīng)生長因了加針灸組)72例,對照組(球后注射生理鹽水加針灸組)46例,進行臨床觀察。兩組均治療3個月。治療前后3個月分別行視力檢查法評定。結(jié)果:治療組總有效率88.9%,對照組總有效率60.9%,差異有極顯著性意義(P<0.005);同吋治療組結(jié)果顯示早期治療效果較好。結(jié)論;球后注射鼠神經(jīng)長
2、因子配合針灸對小兒皮質(zhì)肓較單純針灸組冇明顯的改善作用?!娟P(guān)鍵詞】皮質(zhì)肓/鼠神經(jīng)生長因了;視力障礙/針灸療法;RetrobulbarinjectionofmousenctvcgrowthfactortreatmentofchildrenwithcorticalblindnessClinicalResearchAuthor:CHENXiao,ZHANGMinAddress:Xi'anBrainDiseaseHospitalofTCM,Xi'an710024,China;[Abstract]Objective:Toobservetheballaftertheinjectionofmou
3、senervegrowthfactorontheefficacyofcorticalblindnessinchildrenandimprovetheprognosisinchildren.Methods:2005-01/2009-10Xi,anChinesemedicinehospitalinchildrenwith118casesofencephalopathywererandomlydividedintotwogroups,treatmentgroup(theballaftertheinjectionofmousenervegrowthfactorplusacupunctur
4、egroup)72casesofthecontrolgroup(theballaftertheinjectionofphysiologicalsalineplusacupuncturegroup)46casesofclinicalobservation.Bothgroupsweretreatedfor3months.3monthsbeforeandaftertreatmentweretreatedbyvisualinspectionmethodofevaluation.Results:Thetotaleffectiveratewas88.9%inthecontrolgroup,t
5、hetotalefficiencyof60.9%,thedifferencewashighlysignificant(P<0.001);thesametime,thetreatmentgroupshowedthatearlytreatmenteffectisgood.Conclusions;theballaftertheinjectionofmousenervegrowthfactorinchildrenwithcorticalblindnessacupunctureacupuncturegroupcomparedtothosewithsignificantimprovement
6、.[Keywords】corticalblindness/mousenervegrowthfactor;visuallyimpaired/acupuncturetherapy;小兒皮質(zhì)肓在臨床上不多見,近年來遂著人們對新生兒缺氧缺血性腦病的認識,臨床上發(fā)現(xiàn)小兒皮質(zhì)盲也越來越多見,目前小兒皮質(zhì)盲治療西醫(yī)主要以高壓氧、改善腦供血藥物、營養(yǎng)神經(jīng)藥物治療,中醫(yī)主耍根據(jù)辯證選用針灸、中藥等治療,新興康復醫(yī)學主要以暗室光刺激治療或采用綜合方法治療,臨床均有不同療效;筆者從2005年1月—2009年10月采用球后注射鼠神經(jīng)生長I大I子配合針灸治療皮質(zhì)肓,取得了顯著的療效,現(xiàn)總結(jié)如卜‘:1資料和
7、方法1.1臨床資料:2005-01/2009-10西安中醫(yī)腦病醫(yī)院治療的患兒共118例。男70例,女48例;0.5歲?3歲66例,3歲以上?6歲28例,6歲以上?12歲24例。按隨機、單肓法分為治療組72例和對照組46例。治療組72例,病因包括窣息(宮內(nèi)窒息、生產(chǎn)時窒息)26例,難產(chǎn)、產(chǎn)傷等18例,早產(chǎn)低體重14例,核黃疸后遺癥10例,原因不明者4例,以圍產(chǎn)期病因為主。對照組46例,病因包括窒息10例,早產(chǎn)低體重6例,產(chǎn)傷4例,難產(chǎn)4例,核黃疸后遺癥8例,原因不明者14例。經(jīng)統(tǒng)計