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1、'DepartmentofRehabilitation.QiluHospitalofShandongUniversity?Ji'nan250012,ShandongProvince,China;departmentofNeurology.ShandongDisabledRehabilitationCenter.Ji'nan2501()0,ShandongProvince,ChinaCuiGui-xiang?Chiefphysician.DepartmentofRehabilitation,QiluHospitalofShan
2、dongUniversity.Ji'nan250012.ShandongProvince?Chinacuigx.sdhe@163.comCorrespondence(o:YucShoi卜wci.Doctor.Professor,Docloralsupervisor,DepartmentofRehabilitation,QiluHospitalofShandongUniversity.Ji'nan250012.ShandongProvince?Chinashouweiy@sdu.edu.cnReceived:2008-01-2
3、2Accepted:2OO8-O7-3()干細(xì)胞移植治療脊髓損傷的進(jìn)展崔貴祥仁,李義召2,岳壽偉IAdvancesinstemcelltransplantationforspinalcordinjuryCuiGui-xiang1*2,LiYi-zhao2,YueShou-wei1Abstract:Besidesneuralstemcells,bonemarroworotherderivedmesenchymalstemcells,olfactoryensheathingcells,embryonicstemcells,and
4、umbilicalcordbloodstemcells,theskinoradiposetissues?derivedstemcells,Schwanncells,glialcellsandfibroblastscanalsobetransplantedtotreatspinalcordinjury.Tracingstemcellsinvivoandanalysisbyultrastructure,immunohistochemistryandimagingrevealthattransplantedcellscanmigr
5、ateandgathertotheinjuredregions,survivewellanddifferentiateintoneuralprecursorsorneuralcells,astrocytes,andoligodendroglialcells,expressingspecialmarkers?Inaddilion.lhetransplantedcellscanintegratelothetissuesaroundthelesions,andreducethesizeofthecontusioncavity.Th
6、eaxonregeneratesandiscoveredbynewmyelinsheath.Thesensoryand/orlocomotorrecoveryisimproved?Neurotrophicfactorsplayanimportantroleintheculture,proliferationanddifferentiationofstemcells,andregenerationandrcmyclinationofncuritc?CuiGX,LiYZ,YueSW.Advancesinstemcelltrans
7、plantationforspinalcordinjuiy.ZhongguoZuzhiGongchengYaiijiuyuLinchuangKangfu2(X)8;12(47):9335-9338(0hina)[http://www.crter.cnhttp://en.zglckf.com]摘要：目前發(fā)現(xiàn)，除了神經(jīng)干細(xì)胞、骨髓或其他來(lái)源的間充質(zhì)干細(xì)胞、嗅神經(jīng)勒細(xì)胞以及胚胎干細(xì)胞和臍血干細(xì)胞以外，皮膚來(lái)源.脂肪紐織來(lái)源的干細(xì)胞、許旺細(xì)胞、膠質(zhì)細(xì)胞和成纖維細(xì)胞等均可用于脊髓損傷的細(xì)胞移植治療。體內(nèi)標(biāo)記示蹤以及超微結(jié)構(gòu)、免疫組織化
8、學(xué)和彩像學(xué)等檢查顯示，移植后的干細(xì)胞在神經(jīng)系統(tǒng)內(nèi)可以遷移，在病變部位聚集.存活、分化成為神經(jīng)前體細(xì)胞或神經(jīng)細(xì)胞、星形膠質(zhì)細(xì)胞和少突膠質(zhì)細(xì)胞，分別表達(dá)具特征性標(biāo)志物.并與周I韋I組織整合，軸索再生并有新的艇梢覆蓋，使病變的瘓腔縮小，宿主的感覺(jué)/運(yùn)動(dòng)功能改善。神經(jīng)營(yíng)養(yǎng)因子在干細(xì)胞的培養(yǎng).增殖、
