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1、三種光療法治療尋常性瘞瘡療效觀察[摘要]目的:評(píng)價(jià)光動(dòng)力學(xué)療法(PDT),強(qiáng)脈沖光(IPL)和紅藍(lán)光(LED)治療中、重度尋常性痙瘡的療效。方法:將90例中、重度瘞瘡患者隨機(jī)分為三組:PDT治療組,IPL治療組和LED紅藍(lán)光治療組。分別于治療前、治療中期(治療1個(gè)月)和末次治療結(jié)束后評(píng)價(jià)療效。結(jié)果:治療中期評(píng)價(jià)時(shí),PDT、IPL.LED治療組總有效率分別為93.3%、60.0%和36.7%,平均皮損減少率分別為90.4%、69.0%和39.8%。要達(dá)到炎癥性皮損痊愈,PDT組平均需要(3±1.52)個(gè)治療周期,IPL組(6±2.15)個(gè)治療周期,LED組(9±3.34)個(gè)治療
2、周期。結(jié)論:光療法治療中、重度瘞瘡療效顯著,PDT組療法效果優(yōu)于IPL和LED組,副作用少,有很好應(yīng)用前景,而長(zhǎng)期療效有待進(jìn)一步觀察。[關(guān)鍵詞]光動(dòng)力學(xué)療法;強(qiáng)脈沖光;紅藍(lán)光;尋常性瘞瘡[中圖分類號(hào)]R75&73+3[文獻(xiàn)標(biāo)識(shí)碼]A[文章編號(hào)]1008-6455(2010)10-1515-03EffectivenessofthreephototherapyinthetreatmentofacnevulgarisLIULi-hong,WANGCong-min,FANXin,YAOMei-hua,SUNWei-xin,YANGRong-ya(DepartmentofDermato
3、logy,GeneralHospitalofBeijingMilitaryRegionofPLA,Beijing100125,China)Abstract:ObjectiveToevaluatetheeffectivenessofphotodynamictherapy(PDT),intensepulsedlight(IPL)andlight-emittingdiode(LED)phototherapyforthetreatmentofmoderatetosevereacnevulgaris?Methods90patientswithmoderatetosevereacnewe
4、rerandomlydividedinto3equalgroups:ALA-PDTgroup,IPLgroup,blue-redcombinationLEDgroup.Clinicalassessmentswereconductedbeforestartingtreatment,at1monthasamidpointevaluation,andafterthefinaltreatmentsession.ResultsAtthemid-pointevaluation,incaseofPDT,IPLandLEDgroups,theeffectiveratewere93.3%,60
5、.0%,36.7%,respectively,andthepercentreductionswere90.4%,69.0%,39.8%,respectively.PatientstreatedwiththePDTreacheda^90%clearanceoftheirinflammatorylesionsafterameanof3土1.52sessions,whilepatientstreatedwithIPLrequiredameanof6±2.15sessions?PatientstreatedwiththeLEDrequiredameanof9±3.34sessions
6、?ConclusionsPhototherapyiseffectivetreatmentoptionformoderatetosevereacnewithmildsideeffects?EffectivenessofPDTisthebestinthethreegroup?Vaiidatesfurtherstudiestoevaluatetreatmentsforalongereffectives?Keywords:photodynamictherapy;intensepulsedlight;light-emittingdiode;acnevulgaris尋常性痙瘡為炎癥反應(yīng)引
7、起的丘疹、膿皰、結(jié)節(jié),伴發(fā)或不伴發(fā)非炎癥性粉刺,好發(fā)于青春期,輕者可為生理性粉刺,重者可因炎癥有礙面部美觀。目前,痙瘡的治療方法很多,抗生素和維A酸類藥物是其主要治療方法,但療效不穩(wěn)定。光療是一種有效的治療尋常性痙瘡的新方法,研究顯示可見(jiàn)光的光療,紅藍(lán)光對(duì)炎癥性痙瘡具有明顯的治療效果,副作用?。?]。嚇咻在IPL發(fā)射譜內(nèi)有小的吸收峰,以不同均質(zhì)的組織為靶點(diǎn),光可選擇性被吸收,IPL可作為治療痙瘡的光源⑵。本研究旨在評(píng)價(jià)PDT、IPL、LED光療治療中、重度尋常性痙瘡的療效。1材料和方法1.1儀器及參數(shù):