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1、ConferenCereport
2、news&AnAlysisHottopicsinantibody–drugconjugatedevelopmentAmericanAssociationofPharmaceuticalScientistsNationalBiotechnologyConferenceSheratonSanDiegoHotelandMarina,SanDiego,CA,USA,19–23May2013TheNationalBiotechnologyConference,isapremiermeetingfor
3、biotechnologyprofessionalscoveringabroadrangeofhottopicsinthebiotechnologyindustry.Attractingparticipantsfromacademia,industryandregulatory,thismeetingfeaturessessionsthataimtoaddressemergingsubjectsofinterestandallowsforopenexchangebetweenscientists.The2013confer
4、encefeaturedleadingresearchersinthefieldsofantibody–drugconjugates(ADCs)andimmunogenicity.Herein,wepresentasummaryoftheADChottopics,includingbioanalyticalandPKconsiderations,quantitativeevaluationoftheimpactofimmunogenicityandADMEtounderstandADCdrug–druginteractio
5、ns,andclinicalconsiderationsforADCdevelopment.Thisarticleaimstosummarizetherecommendationsthatweremadebythespeakersduringvarioussessionsthroughouttheconference.ThisConferenceReporthighlightskeyoutcomespapers,withaspecificfocusonbioanalyticalKarenThudium*fromsevera
6、lsessionsfocusedonantibody–drugstrategiesandchallengesforclinicalimmuno&SanelaBilicconjugates(ADCs)atthe2013AmericanAssogenicityandPKassays,drug–druginteractionsNovartisPharmaceuticals,ClinicalciationofPharmaceuticalScientists(AAPS)(DDIs)andinvivocharacterizationo
7、fADCPharmacology,OncologyBusinessNationalBiotechnologyConference,heldinSanbiotransformation.ThecomplexityofmolecUnit,EastHanover,NJ,USA*Authorforcorrespondence:Diego,CA,USAfrom19–23May.TheNationalularandstructuralcharacteristicsofADCsTel.:+18627787862Biotechnology
8、Conference(NBC)iswidelywashighlightedthroughoutthemeetingasaE-mail:karen.thudium@novartis.comattendedbyrepresentativesfromthepharmadrivingfactorinbioanalyticalstrategies,thusceuticalindustry,biotech,regulatoryauthoritiesrequiringearlyinteractionsbetweentheclinical
9、andacademiaintheUSAandEurope.pharmacologist,clinicalteamandmultidisciThetopicofADCsisnostrangertotheNBCplinarybioanalyticalgroupstodevelopnovel–forthepa
