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1、利巴韋林注射液外用治療手足口病皮疹療效觀察doi:10.3969/j.issn.1007-614x.2014.10.41摘要目的:觀察利巴韋林注射液治療手足口病皮疹消退的療效。方法:將65例手足口病患兒隨機(jī)分為治療組35例和對照組30例,兩組均按普通型手足口病患兒給予退熱、補(bǔ)液、口服阿昔洛韋、加強(qiáng)手衛(wèi)生護(hù)理等對癥治療。治療組患兒給予利巴韋林注射液,取適量直接涂敷皮疹處,3?4次/日,連用3?5天;對照組給予爐廿石洗劑外涂皮疹,3?4次/日,連用3~5天。評價兩組治療效果,比較兩組皮疹消退時間、住院時
2、間、體溫恢復(fù)正常時間的差異。結(jié)果:治療組總有效率(97.14%)優(yōu)于對照組總有效率(90.00%),差異有統(tǒng)計(jì)學(xué)意義(P0.05)o結(jié)論:采用利巴韋林注射液外涂手足口病,患兒皮疹消退時間縮短,方法簡單,顯效快,無不良反應(yīng),是臨床治療手足口病安全可靠的選擇。關(guān)鍵詞利巴韋林注射液手足口病皮疹臨床觀察CurativeeffectobservationofribavirininjectioninthetreatmentofrashofhandfootandmouthdiseaseFanXiaoyangDep
3、artmentof卩ediatries,theMaternalandChi1dHea1thHospitalofGuigangCity,GuangxiZhuangAutonomousRegion530000AbstractObjective:ToexploretheeffectofribavirininjectioninthetreatmentofrashofHandfootandmouthdisease.Methods:65patientswithhandfootandmouthdiseasewer
4、erandomlydividedintothetreatmentgroupwith35casesandthecontrolgroupwith30cases.Thetwogroupsweregivensymptomatictreatment,suchasabatementoffever,fluidinfusion,oralacyclovir,strengthenthehandsofhealthcareandsoon.Thetreatmentgroupweregivenribavirininjectio
5、nwhichwasdirectlycoatedrashwithrightamount,3?4times/day,usedfor3~5dayscontinu.Thecontrolgroupwasgivencalaminelotioncoatedwithaskinrash3~4times/day.usedfor3?5dayscontinu.Weevaluatedthetherapeuticeffectsoftwogroups,comparedtheskinrashsubsideddifferencesi
6、ntime,hospitalizationtimeandbodytemperaturereturnedtonormaltimeoftwogroups.Results:Thetotalefficiencyofthetreatmentgroup(97?14%)washigherthan(90%)incontrolgroup,thedifferencewasstatisticallysignificant(卩0.05).Conclusion:Thehandfootandmouthdiseasewascoa
7、tedwithribavirininjectionfortreatment,theskinrashsubsidedtimeofchildrenisshortened,themethodissimple,anditseffectiveisquickandnoadversereaction,soitisasafeandreliablechoicefortheclinicaltreatmentofhandfootandmouthdisease.KeywordsRibavirinTnjection;Hand
8、footandmouthdisease;Rash;Clinicalobservation手足口病是由腸道病毒引起的兒童傳染病,臨床表現(xiàn)以手、足和口腔黏膜皰疹或破潰示形成潰瘍?yōu)橹?,個別重癥患兒病情發(fā)展快可導(dǎo)致死亡,好發(fā)于5歲以下兒童[1]。治療手足口病普通型的文獻(xiàn)相關(guān)研究結(jié)果表明,采用利巴韋林注射液的臨床治療效果與采用傳統(tǒng)爐甘石洗劑臨床治療效果存在不同程度的差異[2?6]。為了進(jìn)一步研究和比較臨床治療手足口病普通型采用利巴韋林注射液外用治療方法的優(yōu)勢,為手足口病普通型的