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1、炎琥寧與利巴韋林治療手足口病療效比較安良敏1安維2國良1(1廣東省英德市人民醫(yī)院513000;2廣東省英德市醫(yī)院513000)【中圖分類號】R725.lL文獻標識碼】A【文章編號】1672-5085(2011)40-0030-02【摘要】目的比較炎琥寧與利巴韋林治療小兒手足口病療效。方法將120例小兒手足口病患者隨機分為二組,炎琥寧組給予炎琥寧5?10mg/kg.d,5%葡萄糖注射液100ml,靜滴,1次/d;利巴韋林組給予利巴韋林10mg/kg.d,5%葡萄糖注射液100ml,靜滴,1次/d;療程7d,比較二組患者臨床療效與癥狀改善時間。結(jié)果炎琥寧組退熱
2、時間為(2.20±1.22)d,口腔潰瘍及手足皰疹消失時間為(3.98±1.18)d,痊愈時間為(4.56±1.42)d,明顯短于利巴韋林組的(3.86±1.36)d、(5.12±1.32)d、(6.58±1.52)d,二組差異有統(tǒng)計意義(P<0.05}。炎琥寧組痊愈29例,顯效18例,有效11例,總有效率為96.7%,利巴韋林組痊愈10例,顯效19例,有效20例,總有效率為81.7%,二組差異有統(tǒng)計學意義(P<0.05)o二組患者均未見明顯不良反應。結(jié)論炎琥寧
3、治療輕中度小兒手足口病的有效率高,癥狀緩解更快,值得臨床推廣應用?!娟P(guān)鍵詞】炎琥寧利巴書林手足口病【Abstract】objectivetocompareinflammationHuningandribavirintherapypediatricHFMDcurativeeffect.Methods120casesofhand,footandmouthdiseaseinchildrenrandomlydividedintotwogroups,inflammationHubettergroupgiveHuinflammationning5?10mg/kg.D,
4、5%glucoseinjectionof100ml,staticdrops,one/d;Ribaviringroupgiveribavirin10mg/kg.D,5%glucoseinjectionof100ml,staticdrops,one/d;Treatment7d,comparestwogroupsofpatientswithclinicalcurativeeffectandthesymptomsimprovetime.TheresultsHubettergroupantifebriletimeinflammationfor(2.20+/-1.22
5、d,oralulcerandbrothersherpesdisappeartimefor(3.98+/-1.18d,recoverytimefor(4.56+/-1.42d,obviousshort,thegroupwoulddomoreharmthangoodWellington(3.86+/-1.36d,(5.12+/-1.32d,(6.58+/-1.52d,twogroupsofdifferencehavestatisticalsignificance(P<0.05).InflammationHubettergrouphealed29),18c
6、ases,effectivegot11cases,thetotaleffectiveratewas96.7%,andribaviringrouphealed10cases,19casesweremarkedlyimproved,effective20cases,thetotaleffectiveratewas81.7%,thetwogroupswasstatisticallysignificantdifference(P<0.05).Twogroupsofpatientstherewerenoobviousadversereactions.Concl
7、usioninflammationHuconservativetreatmentmild-moderatedonorchildrenofhand,footandmouthdisease,highefficiencyofsymptoms,clinicalapplicationisfaster.【Keywords】inflammationHubetterRibavirinHandfootandmouthdisease手足口病是由腸道病毒引起的傳染性疾病,大多發(fā)生于5歲以下的兒童,有較強的傳染性。多數(shù)情況下只能對癥治療,我們比較了炎琥寧與利巴韋林治療輕中癥小兒手
8、足UI病的臨床療效與癥狀緩解時間,現(xiàn)報道如下。1臨床資料與方法1.