資源描述：
《冠狀病毒Coronavirusl論文-1997 Patterns of oligodendrocyte pathology in coronavirus-induced subacute demyelinating encephalomyelitis in the lewis.pdf》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、GLIA19:1±12(1997)PatternsofOligodendrocytePathologyinCoronavirus-InducedSubacuteDemyelinatingEncephalomyelitisintheLewisRatVESNABARAC-LATAS,1GERDASUCHANEK,2HELENEBREITSCHOPF,3ALBERTSTUEHLER,4HELMUTWEGE,5ANDHANSLASSMANN3*1DepartmentofPhysiologyandImmunology,UniversityofRijeka,C-51000Rijeka,Croati
2、a2AustrianAcademyofSciences,A-1010Vienna,Austria3ClinicalInstituteofNeurology,UniversityofVienna,A-1090Vienna,Austria4InstituteofVirologyandImmunology,UniversityofWuerzburg,D-97078Wuerzburg,Germany5InstituteofDiagnosticVirology,FederalResearchCenterforVirusDiseasesofAnimals,Friedrich-Loeffler-In
3、stitutes,D-17498InselRiems,GermanyKEYWORDSdemyelination;remyelination;apoptosis;necrosisABSTRACTIntracerebralinfectionofratswithJHMcoronavirusinducesachronicinˉammatorydemyelinatingdisease,whichinmanyrespectsmimicksthepathologyofmultiplesclerosis.Weinvestigatedthepatternsofdemyelinationandoligod
4、endrocytepathologyinthismodel.InearlystagesofthediseaseinfectionofoligodendrocyteswasassociatedwithadownregulationofexpressionofmRNAforproteolipidproteinintheabsenceofmyelindestruction.Whendemyelinatinglesionswereformedinfectedoligodendrocytesweredestroyedbynecrosis,whereasoligodendrocytesthatdi
5、dnotcontaindetectablevirusantigenorRNAwereinpartdyingbyapoptosis.Atthisstageofthediseaseremyelinationofthelesionswaspronounced.Atlaterstagesafterinfectionvirusantigenwasnearlycompletelyclearedfromthelesions.Inspiteofthelackofdetectablevirus,ongoingdemyelinationandunspeci?ctissuedestructionoccurr
6、ed,andoligodendrocytesweremainlydestroyedbyapoptosis.Theselatelesionsrevealedonlyminimalcentralremyelination,buttheywerefrequentlyrepairedbySchwanncells.Ourstudiessuggestthatthemechanismsofmyelindestructioninthismodelofvirus-induceddemyelinationarecomplexandthatthepatternsoftissuedamagemaychange
7、duringthecourseofthedisease.GLIA19:1±7,1997r1997Wiley-Liss,Inc.INTRODUCTIONstagevirusinfectionisrestrictedtotheglialcellpopulation,equallyaffectingastrocytesandoligodendro-Coronavirus-inducedsubacutedemyelinatingen-cytes.Chr
