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1、JournalofNeuroVirology(1995)1.323-325s01995StocktonPressAllrightsreserved.1355-0284/95S12.00GuesteditorialCoronavirusesCoronavirusesareubiquitousinnature,andinfec-infectsneuronsandcausesasevereencephalitis.tionofmanyavianandmammalianspeciesbytheseDespitethesedifferences,thetotalv
2、iralyieldfrompositivesenseRNAvirusesresultsinimportantthecentralnervoussystemofmiceinfectedwithveterinarydiseases.Inhumans,coronavirusesareJHM(2)andJHM(3)isroughlyequivalentatanytypicallyassociatedwithupperrespiratorytractgiventime,indicatingthattheobserveddifferenceinfectionssuc
3、hasthecommoncold.Mostmurineinpathogenesisismoreamatteroftherelativedis-coronavirusescausehepatitis,withtheresultthattributionofviralinfectionthantheabsolutemagni-thisgroupofvirusesisusuallyreferredtoasmousetudeofviralload.hepatitisviruses(MHV).However,anumberofThus,increasedexpre
4、ssionoftheHEproteinMHVstrains,suchasstrainA59orstrainJHM,areseeninJHM(2)isassociatedeitherwithincreasedveryneurotropic.TheseneurotropicMHVscauseintrinsictropismofthevirusforneuronsormoreinterestingnaturalandexperimentaldiseasesintherapidspreadtoneurons.Thisdifferenceisnotcentraln
5、ervoussystem(CNS)ofrodents.Underabsolute,however,sinceJHM(3)ultimatelydoesdefinedconditions,thesevirusescauseparalysisinfectneurons.SimilarresultshavebeenfoundinandprimarydemyelinationwhichmodelmultipleantibodyescapemutantsofJHMwhichhavesclerosis(KyuwaandStohlman,1990).Also,sever
6、-markedorexclusivetropismfortheglialcellsofalreportshavelinkedcoronavirusestomultiplewhitematterinimmunocompetentmice,butulti-sclerosistissuedirectly,althoughthisremainsanmatelywillinfectneuronsinimmunosuppressedareaofcurrentcontroversyandinvestigationmice(Flemingetal,1987andunpu
7、blishedobserva-(Murrayetal,1992;Stewartetal,1992).tions).Theseresultsmayperhapsbestbeconceptu-InthisissueoftheJournalofNeurovirologytwoalizedastheresultsofa‘race’intheCNSbetweeninterestingpapersexploredifferentaspectsofcoro-thevirusandthehostimmunesystem.Glialcellsnavirusespathog
8、enesis.ThepaperbyYokomoriandoutnumberneu
