資源描述：
《冠狀病毒Coronavirusl論文-1979 Comparison of the morphology of three coronaviruses.pdf》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、ArchivesofVirologyArchivesofVirology59,25--33(1979)?bySpringer-Veriag1979ComparisonoftheMorpholofyofThreeCoronavirusesByHEATHER,A.DAVIESandM.R.MACNAUGI~ITO~NSectionofElectronMicroscopyandDivisionofCommunicableDiseases,ClinicalResearchCentre,Harrow,Middlesex,EnglandWi
2、th3FiguresAcceptedAugust22,1978SunlnlaryThemorphologyofthreecoronaviruses;avianinfectiousbronchitisvirusstrainConnecticnt(IBVConn),humaneoronavirusstrMn229E(HCV229E)andmousehepatitisvirusstrain3(MHV3),wereexaminedbynegativestaining.Significantdifferenceswerefoundinth
3、esizesofthethreecoronaviruses.Further-more,threetypesofsurfaceprojectionofthesamelengths,butvaryingwidthsandmorphology,wereobserved.BothIBVCormandHCV229Ehadbulbousprojec-tionscharacteristicofcoronaviruses,althoughtheprojectionsofHCV229EweresomewhatthinnerthanthoseofI
4、BVConn.Ontheotherhand,MHV3particleshadthin,cone-shapedsurfaceprojections,thatwerecompletelyunliketypicalcoronavirusprojections.Thesignificanceoftheseresultsisdiscussed.IntroductionCoronavirusesareagroupoflipid-contMningRNAvirusesthathaveauniquemorphology(15,22).Thevi
5、rionsareusuallydescribedasbeinglargepleomorphicsphericalparticleswithcharacteristicbulbous,wideLy-spacedsurfaceprojectionsthatformacoronaaroundtheparticles(15).Thevirusenvelopecontainslipidandappeaxstoconsistofadistinctpairofelectrondenseshells(15)andasingle-stranded
6、helicalinternalcomponentthathasbeenidentifiedasribonueleoprotein(10).Atpresent,coronavirusesareclassifiedalmostentirelybymeansoftheircharacteristicmorphology,andalthoughpreliminarybiochemicalandserologicalcriteriaarenowavailableforsomecoronaviruses(22),therelativedif
7、ficultyinisolatingandgrowingsomeofthesevirusesincellcultureforbiochemicalanalysismeansthatforsometimeitwiltbenecessarytoclassifymanycoronavirusesentirelybytheirmorphologicalfeatures.Measurementsofthesizesoivariouscoronavirusspeciesbydifferentin-vestigatorsusingnegati
8、vestaininghaverevealedalargerangeintotaldiameters0304-8608/79/0059/0025/$01.8026HEATHERA.DAvIEsandM.R.MACI~AUGtITOI~:ofbetween50and
