冠狀病毒Coronavirusl論文-2005 [Advances in Virus Research] Virus Structure and Assembly Volume 64 __ Molecular Interactions in the Assembly of Co.pdf

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1、ADVANCESINVIRUSRESEARCH,VOL64MOLECULARINTERACTIONSINTHEASSEMBLYOFCORONAVIRUSESCornelisA.M.deHaanandPeterJ.M.RottierVirologyDivision,DepartmentofInfectiousDiseasesandImmunologyFacultyofVeterinaryMedicine,UtrechtUniversity3584CLUtrecht,TheNetherlandsI.

2、IntroductionII.StructureoftheCoronavirionandItsComponentsA.CoronavirionB.ViralGenomeC.NProteinD.MProteinE.EProteinF.SProteinG.HEProteinIII.UltrastructuralObservationsofCoronavirusMorphogenesisA.ViralBuddingB.PostassemblyMaturationofVirionsIV.Molecula

3、rInteractionsinAssemblyoftheCoronavirionA.NucleocapsidAssemblyB.EnvelopeAssemblyC.VirionAssemblyV.PerspectivesReferencesI.INTRODUCTIONVirusesaremultimolecularassembliesthatrangefromsmall,regu-lar,andsimpletolarge,pleiomorphic,andcomplex.Theyconsistof

4、virus-speci?edproteinsandnucleicacidsand,inthecaseofenvelopedviruses,ofhost-derivedlipids.Ininfectedcellstheassemblyofthesedifferentcomponentsintovirionsoccurswithhighprecisionamidstahugebackgroundoftensofthousandsofhostcompounds.Twokeyfactorsdetermi

5、netheef?ciencyoftheassemblyprocess:intracellulartransportandmolecularinteractions.Directionaltransportensurestheswiftandaccuratedeliveryofthevirioncomponentstothecellularcompartment(s)wheretheymustmeetandform(sub)structures.Somevirusesachievethisgoal

6、rel-ativelysimplywhengenomeproductionoccursincloseproximity165Copyright2005,ElsevierInc.Allrightsreserved.0065-3527/05$35.00DOI:10.1016/S0065-3527(05)64006-7166CORNELISA.M.DEHAANANDPETERJ.M.ROTTIERtothevirionassemblysite(e.g.,picornaviruses).Manyviru

7、ses,how-ever,haveevolvedmoreelaboratestrategies.Thisisillustrated,forinstance,bythea-herpesviruses.AssemblyofthesevirusesstartsinthenucleusbytheencapsidationofviralDNA,usingcytoplasmicallysynthesizedcapsidproteins;nucleocapsidsthenmigratetothecyto-so

8、l,bybuddingattheinnernuclearmembranefollowedbydeenvelop-ment,topickupthetegumentproteins.Subsequently,thetegumentedcapsidsobtaintheir?nalenvelopebybuddingintovesiclesofthetrans-Golginetwork(TGN),wheretheviralenvelopeproteinshavecongre-gatedaftertheir