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1、張愛珍zhangAizhen浙江大學城市學院醫(yī)學與生命科學學院膳食纖維與體重控制Dietaryfiberandweightmanagement膳食纖維與體重控制Dietaryfiberandweightmanagement膳食纖維攝入量與體重、體脂呈負相關Mostbutnotallobservationalstudiesshowedaninverse,sometimesdose-dependentrelationshipbetweenDFconsumptionandbodyweight水溶性膳食纖維和非水溶性膳食纖維富含膳食纖維的天然食物和膳食纖維制劑Ge
2、nerally,inhumanstudies,nocleardifferenceregardingweightgainhasbeenshownbetweensolubleandinsolubleDFandfermentableandnonfermentableDF,orbetweenfoodsnaturallyhighinDFandfibersupplementsEpidemiologicsupportthatDFintakepreventsobesityisstrong對體重控制效果類似膳食纖維與體重控制Dietaryfiberandweightmana
3、gement膳食纖維控制體重的可能機制1含親水基團，吸水膨脹性飽腹感2粘性、吸附性延緩饑餓感34減少營養(yǎng)素吸收5改變腸道激素分泌在大腸內發(fā)酵代謝提供能量較少Interventionstudies：theadditionofdietaryfibergenerallydecreasesfoodintakeand,hence,bodyweight.Mechanisms：InducinggreatersatiationandsatietyDecreasingabsorptionofmacronutrientsAlteringsecretionofguthormon
4、esDecreasinginenergyintakeandbodyweightlossmechanisms國外的研究：膳食纖維與體重控制DietaryfiberandweightmanagementHowarthetal:meanvaluesforpublishedstudiesindicatethatconsumptionofanadditional14g/dayfiberfor>2daysisassociatedwitha10%decreaseinenergyintakeandbodyweightlossof1.9kgover3.8monthsmean
5、energyintakeinallstudieswasreducedto82%byhigherfiberintakeinoverweight/obesepeopleversus94%inleanpeople;bodyweightlosswas2.4kgversus0.8kgEpidemiologicsupportthatDFintakepreventsobesityisstrong補充DF14g/d能量攝入：減少10%（消瘦者：6%肥胖/超重者：18%）體重：減輕1.9kg（消瘦者：0.8kg肥胖/超重者：2.4kg）對超重/肥胖癥患者減輕體重的效果優(yōu)于健
6、康體重者obeseindividualsmayexhibitagreatersuppressionofenergyintakeandbodyweightloss實驗各組大鼠體重的變化情況(g，)組別實驗前體重第2周第6周空白對照組203.5±8.5264.4±19.7367.7±29.4高脂模型組202.2±9.4281.2±16.8☆☆401.7±33.2☆☆MCP低劑量組204.5±7.8287.3±13.1☆☆396.1±31.8☆☆MCP中劑量組203.6±7.3284.7±12.6☆☆398.3±21.5☆☆MCP高劑量組202.5±8.4276
7、.8±12.5☆383.2±30.9我們的研究：MCP對肥胖大鼠血脂及瘦素的調節(jié)StudyofDFinrat實驗各組大鼠臟體比的變化情況(g，)組別3周后肝體比3周后腎體比6周后肝體比6周后腎體比空白對照組2.76±0.220.72±0.032.70±0.160.70±0.06模型對照組3.98±0.31☆☆0.76±0.044.45±0.68☆☆0.67±0.07MCP低劑量組4.06±0.30☆☆0.73±0.024.17±0.49☆☆0.66±0.06MCP中劑量組4.12±0.21☆☆0.74±0.043.93±0.38☆☆△0.64±0.05☆M
8、CP高劑量組4.04±0.45☆☆0.74±0.023.66±0.
