不同劑量地佐辛對(duì)瑞芬太尼靜脈全麻術(shù)后蘇醒期的影響

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1、HainanMedJ，Dec．2013，Voi．24,No．23海南醫(yī)學(xué)2013年12月第24卷第23期doi：lO．3969／j．issn．1003—6350．2013．23．1446·論著·不同劑量地佐辛對(duì)瑞芬太尼靜脈全麻術(shù)后蘇醒期的影響羅小玲，歐陽(yáng)偉子，趙麗(深圳市第七人民醫(yī)院麻醉科，廣東深圳518081)【摘要】目的研究不同劑量地佐辛對(duì)腹腔鏡手術(shù)患者瑞芬太尼靜脈全麻術(shù)后蘇醒期的影響。方法選擇100例腹腔鏡手術(shù)患者，按隨機(jī)數(shù)字表法分為實(shí)驗(yàn)組四組(T1組、T2組、T3組、T4組)和對(duì)照組(c組)，每組20例。行雙盲試驗(yàn)。在麻醉深度監(jiān)測(cè)下行麻醉誘導(dǎo)及維持，維持藥物為丙泊酚+瑞芬太

2、尼，術(shù)畢前15min，T1組、T2組、T3組、T4組分別靜注地佐辛80~teCkg、60~tg／kg、40~g／kg、20~tg／kg，C組靜注生理鹽水1Oml，觀察患者睜眼時(shí)間、呼吸恢復(fù)時(shí)間、拔管時(shí)間、疼痛視覺(jué)模擬評(píng)分(VAS)、惡心嘔吐及躁動(dòng)不良反應(yīng)。結(jié)果T1組、T2組的睜眼時(shí)間、呼吸恢復(fù)時(shí)間、拔管時(shí)間明顯較T3組、T4組和C組延長(zhǎng)(P

3、鏡；蘇醒期【中圖分類號(hào)】R614．2【文獻(xiàn)標(biāo)識(shí)碼】A【文章編號(hào)】1003---6350(2013)23—3479__o2Efectsofdezocineofdiferentdosesonremifentanilintravenousgeneralanesthesiapostoperativerevivalperiodunderthedepthofanesthesiamonitoring．LUOXiao-ling,OUYANGWei-zi，ZHAOLi．DepartmentofAnesthesiology,theSeventhPeopleHospitalofShenzhen,Shen

4、zhen518081，Guangdong,CHINA【Abstract】ObjectiveToresearchtheefectsofdezocineofdiferentdosesonremifentanilintravenousgen—eralanesthesiapostoperativerevivalperiodunderthedepthofanesthesiamonitoring．MethodsAtotalof100lapa—roscopicsurgerypatientswereselectedanddividedinto4experimentalgroups(T1，T2，T3

5、，T4)andcontrolgroup(groupC1randomly,、m20casesineachgroup．Administerinductionandmaintenanceofanesthesiawereperformedbyusingremifentanilandpropofolunderthedepthofanesthesiamonitoring．Tenminutesbeforetheendofsurgery,in—travenousdezocinetothegroupTintheunitsof8O!．tg／kg，60~tg&g，40~tg／kg，20ug／kgresp

6、ectively,10mlofsalinetogroupC．Recoverytimeofspontaneousbreathing，eyeopeningtime，extubationtime，alert／sedationscore(OAA／S)，vi-sualanaloguescale(VAS)andadversereactionsofnausea，vomitinganddysphasiawereobserved．ResultsThere．coverytimeofspontaneousbreathing，eyeopeningtimeandextubationtimeingroupT1

7、andT2werelongerthanthoseingroupT3，T4andCsignificantly(P<0．05)，butOAA／Swaslower(P<0．05)．TheVASanddysphoriaincidenceingroupT4andCweresignificantlyhigherthanthoseinothergroups．ConclusionAppropriatedoseofdezocineCanef-fectivelypreventpainan