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《奧美拉唑、蘭索拉唑和泮托拉唑預(yù)防重癥腦卒中患者應(yīng)激性潰瘍的成本-效果分析》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、臨床合理用藥2013年l1月第6卷第l1期中ChinJofChmc~RationalDrugUse。November2013，VoL6No．1lB·5··論著·奧美拉唑、蘭索拉唑和泮托拉唑預(yù)防重癥腦卒中患者應(yīng)激性潰瘍的成本一效果分析池寧娟，賈艷艷，趙先，鹿成韜，竇芳，文愛東【摘要】目的探討3種質(zhì)子泵抑制劑預(yù)防重癥腦卒中患者應(yīng)激性潰瘍的成本一效果。方法310例重癥腦卒中患者隨機(jī)分為3組；A組105例，B組102例，c組103例。3組均予常規(guī)治療，A組采用奧美拉唑預(yù)防，B組采用蘭索拉唑預(yù)防，c組采用泮托拉唑預(yù)
2、防。比較各組的潰瘍發(fā)生率、醫(yī)院獲得性肺炎發(fā)病率和總病死率，并進(jìn)行成本一效果分析。結(jié)果3組潰瘍發(fā)生率、預(yù)防應(yīng)激性潰瘍出血的有效率比較差異無統(tǒng)計學(xué)意義(P>0．05)。與B組和c組比較，A組醫(yī)院獲得性肺炎發(fā)病率較高，差異有統(tǒng)計學(xué)意義(P<0．05)；A組、c組病死率比較差異有統(tǒng)計學(xué)意義(P<0．05)，B組和c組比較差異無統(tǒng)計學(xué)意義(P>0．05)。3組成本—效果分別為23．5，23．1和11．4。結(jié)論泮托拉唑成本效果優(yōu)于奧美拉唑和蘭索拉唑?！娟P(guān)鍵詞】奧美拉唑；蘭索拉唑；泮托拉唑；重癥腦卒中；應(yīng)激性潰瘍；成本
3、—效果分析【中圖分類號】R573．1【文獻(xiàn)標(biāo)識碼】A【文章編號】1674—3296(2013)11B一0005—02Cast-efectivenessanalysisofomeprazole．iansoprazoleandpantoprazoleinthepreventionofsIessulcerinpatientswithseverecerebralstrokeCHINing-juan，JIAYan-yan，ZHAOXian，eta1．HospitaloftheFourthMilitaryMedica
4、lUniversity，Xian，Shanxi710032，China【Abstract】ObjectiveToinvestigatethecost-efectivenessofcmeprazole，lansoprazoleandpantoprasoleinthepre—ventionofstressulcerinpatientswithseverecerebralstroke．Methods310casesofpatientswithSeverestrokewererandom-lydividedint
5、o3groups8．8groupA(105cases)，groupB(102cases)andgroupC(103cases)．The3groupsweregivenconventionaltherapy，thegroupAWaspreventedwithomeprazole，thegroupBWaspreventedwithlansoprazole，thegroupCWaspreventedtllpantoprazole．Theincidenceofulcer，theincidenceofh0spita
6、lacquiredpneumoniaandtheoverallmortalityratewereobservedandcomparedinthe3groups．Anddocostefectivenessanalysis．ResultsThereweresignificantdiferencesinaspectofincidenceofulcer，eficiencyrateofstressulcerbleedingpreventioninthe3groups(P<0．05)．Theincidenceofh0
7、spitalacquiredpneumoniaofgroupAWashigherthanthatofgroupBandgroupC，andthediferenceWasstatisticallysisni~-cant(P<0．05)．ThereWassignificantdiferenceinaspectofmortalityratebetweengroupAandgroupC(P<0．05)，butthereWasnosignificantbetweengroupBandgroupC(P>0．05)．T
8、hecost—efectii,enessofwasrespectively23．5，23．1and11．4．CondusionsThecost．efectivenessofpantoprazoleisbetterthanthatofomeprazoleandlansoprazole．【Keywords】Omeprazole；Lansoprazole；Pantoprazole；Severecerebralstroke；Stres
