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1、萬(wàn)方數(shù)據(jù)CHINESEJOURNALoFANATOMYV01．30No．62007解剖學(xué)雜志2007年第30卷第6期黃芪建中湯對(duì)脾虛型慢性萎縮性胃炎大鼠消化系統(tǒng)的影響。劉旺根1蔣時(shí)紅1(1河南中醫(yī)學(xué)院解剖學(xué)與組織胚胎學(xué)學(xué)科，鄭州王琦1王雪萍1昊景蘭2450003；2鄭州大學(xué)組織學(xué)與胚胎學(xué)教研室，鄭州450052)、摘要目的：探討黃芪建中湯對(duì)慢性萎縮性胃炎(CAG)的療效及其機(jī)制。方法：將24只Wismr大鼠隨機(jī)分為正常對(duì)照組(C)、CAG組、維酶素(V)組、黃芪建中湯(HJD)組，觀察大鼠胃黏膜、空腸黏膜、肝和胰外分泌部組織中的糖
2、原含量、SDH、LDH、ANAE和ACP活性。結(jié)果：與正常大鼠相比，CAG組大鼠一般狀況欠佳，體質(zhì)量明顯減輕；大鼠胃黏膜萎縮、變薄，胃黏膜炎癥程度積分和胃黏膜糜爛程度積分明顯升高，而胃黏膜厚度和腺管總長(zhǎng)度明顯降低；空腸和肝也呈現(xiàn)出不同程度的病理學(xué)改變；大鼠上述臟器的糖原含量、SDH、ANAE、ACP和LDH活性多數(shù)顯著降低；經(jīng)黃芪建中湯治療21d后，上述指標(biāo)明顯改善并明顯優(yōu)于維酶素組。結(jié)論：脾虛型CAG狀態(tài)下，機(jī)體存在多臟器代謝紊亂，黃芪建中湯對(duì)之有良好的復(fù)健作用，其療效顯著優(yōu)于維酶素。關(guān)鍵詞黃芪建中湯；慢性萎縮性胃炎；脾虛；組織
3、代謝；大鼠EffectsofHuangqiJianzhongDecoctiononthedigestivesystemofratwithchronicatrophicgastritiswithsyndromeofspleendeficiency+LiuWanggenl，JiangShihon91，WangQil，WangXuepin91。WuJinglanz(1DepartmentofHistologyandEmbyology，HenanCollegeofTraditionalChineseMedicine，Zhengzhou45
4、0003，China；2DepartmentofHistologyandEmbryology，ZhengzhouUniversity，Zhengzhou450052，China)AbstractObjective．TostudythemechanismfortherapeuticeffectsofHuangqiJianzhongDecoction(HJD)onratmodelsofchronicatrophicgastritis(CAG)ofspleendeficiencytype．Methods：24Wistarratswere
5、randomlydividedintocontrol(C)group，CAGgroup，vitacoenzyme(V)groupandHJDgroup．SDH，LDH，ANAE，ACPandglyco-geninthestomachmncosa，junummucosa，liverandpancreasexocrinepartwereexaminedineachgrouprespective-lY．Results：ComparedwiththeCgroup。thebodyqualityinCAGgroupwasreducedmark
6、edlywithgeneralweakness．Thegastricmucosaebecameatrophyandthinnerwithobviouserosionandmoreinflammatorycells．Thestructuresofthejejunumandliveralsoweredestroyed．TheexpressionsofSDH，LDH，ANAE，ACPandglycogenwereweaker．Thereweresignificantdifferencesinallaboveparametersbetwe
7、entheCAGgroupandCgroup，andtheHJDgroupandVgroup．Conclusion：、7lmenchronicatrophicgastritis(CAG)withsyndromeofspleendeficiencyhappened，themetabolismisdisorderinseveralorgansasabove，whichcouldbeimprovedbyHJD．ThetherapeuticeffectsofHJDpredominatedovervitacoenzyme．KeywordsH
8、uangqiJianzhongDecoction；ch．ronicatrophicgastritis；syndromeofspleendeftciency；metabolism；rat現(xiàn)代中醫(yī)研究認(rèn)為慢性萎縮性胃炎(chronica—trophic
