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1、一228一中華內(nèi)分泌外科雜志2010年8月第4卷第4期ChinJEndocrSurg，August2010，Vo1．4，No．4·臨床研究·斜坡異位垂體腺瘤2例并文獻(xiàn)復(fù)習(xí)劉斌王勇【摘要】目的探討罕見的斜坡異位垂體腺瘤的臨床和影像學(xué)特點(diǎn)、診斷和治療。方法對(duì)我院收治的2例經(jīng)病理證實(shí)為斜坡異位垂體腺瘤進(jìn)行觀察，簡要復(fù)習(xí)相關(guān)文獻(xiàn)，總結(jié)其臨床、神經(jīng)影像、診斷和治療等方面的特點(diǎn)。結(jié)果臨床表現(xiàn)為內(nèi)分泌紊亂或／和神經(jīng)功能障礙癥狀，影像檢查均顯示斜坡部位塊影。1例術(shù)前診斷為異位垂體腺瘤；1例術(shù)前誤診為脊索瘤。均采用單鼻孔一蝶竇入路，顯微手術(shù)切除腫
2、瘤。1例鏡下腫瘤全切，術(shù)后激素水平降至正常，隨訪1年無復(fù)發(fā)；1例部分切除，術(shù)后并發(fā)腦脊液鼻漏和顱內(nèi)感染，治愈后失訪。結(jié)論斜坡異位垂體腺瘤主要表現(xiàn)為內(nèi)分泌紊亂或／和神經(jīng)功能障礙癥狀，顱腦MRI具有一定的診斷價(jià)值。盡管罕見，斜坡部位腫瘤的鑒別診斷也應(yīng)考慮此類腫瘤；手術(shù)全切腫瘤可獲得理想的療效?！娟P(guān)鍵詞】異位垂體腺瘤；斜坡【中圖法分類號(hào)】R736．4【文獻(xiàn)標(biāo)識(shí)碼】BEctopicpituitaryadenomainclivus：2casesreportandreviewoftheliteratureLIUBin，WANGy0．Depa
3、rtmentofNeurosurgery，HenanProvincialHospital，Zhengzhou450003，ChinaCorrespondingauthor：L1UBin，Email：brain1988cn@yahoo．corn．cn【Abstract】ObjectiveToexploreclinicalandneuroimaginefeatures，aswellasthemanagementofrareectopicpituitaryadenonminclivus．MethodsWereportedtwocase
4、sofectopicpituitaryadenomaverifiedbyhistologyintheclivusregion，reviewedtherelevantliteraturebriefly，summarizedtheclinicalandneuroimagingfeatures，alongwiththemanagementofeetopicpituitaryadenomainelivus．ResultsEctopicpituitaryadenomainclivuscausedsymptomsofendocrinopat
5、hyand／orneurologicaldysfunction．hnagingstudiesshowedanoccup—yinglesionintheclivus．Pituitaryadenomawasdiagnosedinonepatientpreoperatively，theotherwasdiagnosedaschordoma．Thetumorsweremierosurgicallyremovedthroughthetrans—sphenoidalroute．Tumorwasradicallyremovedinonepat
6、ient，andduringoue—yearfollow—up，therewasnorecurrence．Theotherwaspartiallyresec—ted，andsufferedpostoperativecerebrospinalfluidrhinorrheaandintracranialinfection，follow—upofthispatientlostfinally．ConclusionsThepatientswitheetopicpituitaryadenomainclivushaveendoerinopat
7、hyor／andneurologicaldysfunction，andMRIplaysavaluableroleinthediagnosis．Althoughextremlyrare，ectopicpituita—rytunlourneedstobeconsideredincaseofanoccupyinglesionintheclivus．Radicalresectionoftunlorcancurethepatient．【KeyWords】Ectopicpituitaryadenoma；Clivus垂體腺瘤幾乎均源于鞍內(nèi)，當(dāng)
8、腫瘤增大時(shí)可向顱例1：肢端肥大4年，多食、多飲、多尿1月余收治。內(nèi)、外擴(kuò)展至鞍上或／和蝶竇等處；發(fā)生于上述部位之入院檢查：消瘦，肢端肥大。左眼視力0．6，右眼0．5，外的垂體腺瘤稱為異位垂體腺瘤。盡管異位垂體腺瘤視野無異常。空腹血糖18．38mmol／L，血生長
