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《β-欖香烯聯(lián)合順鉑對(duì)宮頸癌SiHa細(xì)胞增殖和凋亡的影響-論文.pdf》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫(kù)。
1、見(jiàn)代腫瘤醫(yī)學(xué)2014年2月第22卷第2期MODERNONCOLOGY，F(xiàn)eb20f4，VOL．22，NO02·265B一欖香烯聯(lián)合順鉑對(duì)宮頸癌SiHa細(xì)胞增殖和凋亡的影響馬力天，任秦有，史恒軍，閆平。，魏忠海。，李棟棟，宿仕民，周艷，林艷云，鄭瑾Efectof13一ElemenecombinedwithDDPontheproliferationandapoptosisofSiHacelMaLitian一，RenQinyou，ShiHengjun，YanPing。，WeiZhonghai。，LiDongdong，SuShimin，ZhouYan，LinYanyun，ZhengJin
2、’DepartmentIntegratedTraditionalandWes~rnMedicineofOncology，TangduHospital，TheFourthMilitaryMedicalUniversity，Shaanxi皿a710038，China；StudentTeams，TheFourthMilitaryMedicalUniversity，ShaanxiXi"an710032，China；65547MilitaryHospital，LiaoningHaicheng114200，China；DepartmentRadiationMedicine，TheFourth
3、MilitaryMedicalUniversity，ShaanxiXi"an710032，China；DepartmentddChineseMedicine，ChinesePLAGeneralHospital，Beijing100853，China．【Abstract】Objective：ToinvestigatetheeffectofB—ElelnenecombinedwithDDPontheproliferationandapop—tosisofSiHacellMethods：DifferentconcentrationsofB—Elelneneinjection(25，50
4、，100，150，200b~g／m1)andDDP(15，3，6，9，l2ln1)weresoloappliedtoSiHacelsCelproliferationwasnleasuredbyCCK一8(CelCountKit一8)Theappropriatedrugconcentration(3mlDDP，l25g／lnlp—Elelnene)wereselectedThen，p—E1一enlenecombinedwithDDPinjectionwasappliedtoSiHacelsCellproliferationwasnleasuredbyCCK一8Cellapop—to
5、siswasdetectedbyfloweytolnetryResults：CdlproliferationwasdramaticalyinhibitedbyB—Elelneneinjection(25，50，100，150，200b~g／ln1)andDDP(15，3，6，9，l2g／ln1)at24h，48h(P<005)inaddition，cellprolifera—tionwasdramaticallyinhibitedbyinjectionB—ElelnenecombinedwithDDPCombinationtherapy，apoptosisrateandinhib
6、itionrateofproliferationinSiHacellstreatedbyB—ElenlenecombinedwithDDPwerehigherthanthel~lOnO—therapy(P<0f)1)Conclusion：DDP，B—Elel~leneandDDPcombinedwithelenlenecaninhibittheproliferation，acceleratetheapoptosisinSiHacellsDDPcombinedwithB—ElelnenehavesynergisticeffectontheapoptosisinSi—Hacalls【
7、Keywords】Eleinene；DDP；SiHacdl；proliferation；apoptosisModernOncology2014，22(02)：0265—0268【摘要】目的：探討B(tài)一欖香烯聯(lián)合順鉑對(duì)宮頸癌SiHa細(xì)胞生長(zhǎng)的影響。方法：體外培養(yǎng)宮頸癌SiHa細(xì)胞，分別將p一欖香烯(濃度梯度為25、50、100、150、200m1)，順鉑(濃度梯度為15?369、l2ln1)，單獨(dú)作用于宮頸癌SiHa細(xì)胞，加藥24h、48h后用CCK一8法檢測(cè)細(xì)胞增殖情況。用流式細(xì)胞
