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1、海南醫(yī)學(xué)院學(xué)報(bào)2014,20(5)700JournalofHainanMedicalUniversityDOI:10.13210/j.cnki.jhmu.20140124.082網(wǎng)絡(luò)出版地址:http://www.cnki.net/kcms/doi/10.13210/j.cnki.jhmu.20140124.082.html變應(yīng)性鼻炎患者血清白細(xì)胞介素含量檢測及臨床價(jià)值闕鎮(zhèn)如,冉騫,林丹琪,張智斌,蔡繼一,許玉,黃欽輝(解放軍第180醫(yī)院耳鼻咽喉科,福建泉州362008)[摘要]目的:研究變應(yīng)性鼻炎患者血清白細(xì)胞介素含量及臨床價(jià)值。方法:選取在我院就診的變應(yīng)性鼻炎患者納入研究的觀察組,同期在我
2、院接受體檢的健康者納入研究的對照組,檢測血清白細(xì)胞介素一4(IL一4)、白細(xì)胞介素-5(IL一5)、白細(xì)胞介素一17(IL一17)、白細(xì)胞介素一33(IL一33)含量以及氣道功能指標(biāo),并進(jìn)行臨床癥狀評分。結(jié)果:(1)觀察組的IL一4、IL一5、IL一17、IL一33水平高于對照組;(2)觀察組的最大呼氣流速(PEF)、一秒率(FEV1/FVC)均低于對照組,噴嚏、流涕、鼻塞、鼻癢評分均高于對照組;(3)血清IL一4、IL一5、IL一17、IL-33水平與PEF、FEV1/FVC呈負(fù)相關(guān),與噴嚏、流涕、鼻塞、鼻癢評分呈正相關(guān)。結(jié)論:血清白細(xì)胞介素含量且具有檢測方便、客觀性強(qiáng)的優(yōu)勢,能夠便捷、準(zhǔn)確
3、、客觀的反應(yīng)變應(yīng)性鼻炎患者的整體病情,臨床應(yīng)用價(jià)值明確。[關(guān)鍵詞]變應(yīng)性鼻炎;白細(xì)胞介素;氣道功能[中圖分類號]R765.21[文獻(xiàn)標(biāo)識碼]B[文章編號]1007—1237(2014)05—0700—04SeruminterleukinlevelsinallergicrhinitispatientsanditsclinicalvalueQUEZhen—FH,RANQian,LINDan—qi,ZHANGZhi—bin,CAIJi—Yi,XUYu,HUANGQin—hui(Departmentof0£0rn0£nrg0Z0g,Quanzhou180HospitalofPLA,Quanzhou36
4、2008,China)[FoundationBect]:ScienceandTechnology&口“of@anzho~(2012z59)[Author]:QUEZhen—rbt(1964一),Male,YongdingFujian,M.B.,DeputyChiefPhysician,Tel:13313835711,E-mail:qzrl80@163.com.Received:2014—01—15Revised:2O14—01—21JHMC,2014;20(5):700—703Viewfromspecialist:Itiscreative,andofcertainscientifieanded
5、ucationalvalue.[ABSTRACT]Objective:Toinvestigatetheseruminterleukinlevelsinallergicrhinitispatientsanditsclinicalvalue.Methods:Allergicrhinitispatientsadmittedtoourhospitalwereenrolledasobservationgroupandhealthypeopleunderwentphysicalexaminationwereenrolledascontrolgroup.ThenserumIL一4,IL一5,IL一17,II
6、一33contentandairwayfunctionweredetected,clinicalsymptomscorewereevaluated.Results:(1)IL一4,IL一5,IL一17,IL一33contentsofobservationgroupwerehigherthanthoseofcontrolgroup;(2)PEF,F(xiàn)EV1/FVCofobservationgroupwerelowerthanthoseofcontrolgroup,nasalitch—ing,nasalcongestion,runnynose,sneezingscoreofobservationgr
7、oupwerehigherthanthoseofcontrolgroup;(3)II一4,II一5,IL一17,IL一33contentswerenegativelycorrelatedwithPEF。FEV1/FVCandposi—tivelycorrelatedwithnasalitching,nasalcongestion,runnynose,sneezingscore.Conclusion