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《血清降鈣素原定量檢測(cè)在兒科血流感染診斷中的應(yīng)用價(jià)值-論文.pdf》由會(huì)員上傳分享,免費(fèi)在線閱讀,更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫(kù)。
1、·l734·國(guó)際檢驗(yàn)醫(yī)學(xué)雜志2014年7月第35卷第13期IntJLabMed,July2014,Vo1.35,No.13·臨床檢驗(yàn)研究論著·血清降鈣素原定量檢測(cè)在兒科血流感染診斷中的應(yīng)用價(jià)值黃燕新,姜朝新,冼潔能,晏文芬(廣東省佛山市南海區(qū)第三人民醫(yī)院檢驗(yàn)科,廣東佛山528244)摘要:目的探討血清降鈣素原(PCT)定量檢測(cè)在兒科血流感染診斷中的價(jià)值。方法回顧性分析某院183例同時(shí)送檢血液培養(yǎng)和PCT檢測(cè)的結(jié)果,以血培養(yǎng)為金標(biāo)準(zhǔn),把患者分為非血流感染組和血流感染組,比較兩組間血清PCT濃度的差異。兩組間PCT值差異比較采用Mann-WhitneyU檢驗(yàn),P<0.0
2、5為差異有統(tǒng)計(jì)學(xué)意義。結(jié)果非血流感染組血清PCT濃度為0.15(0.065~0.55)ng/mI,血流感染組血清PCT水平為1.11(0.505~8.975)ng/ml,兩組間的血清PCT濃度差異有統(tǒng)計(jì)學(xué)意義(P:0.000);以O(shè).5Ong/mI為界點(diǎn),PCT診斷的靈敏度為77.8、特異度為73.3,陽(yáng)性預(yù)測(cè)值和陰性預(yù)測(cè)值分剮為24.1%和96.8。結(jié)論定量檢測(cè)PCT可輔助快速排除或診斷血流感染,為避免抗菌藥物的過(guò)度使用或早期抗感染治療提供參考。關(guān)鍵詞:降鈣素原;血流感染;診斷DOI:10.3969/j.issn.1673—413O.2O14.13.029文獻(xiàn)標(biāo)識(shí)
3、碼:A文章編號(hào):1673—4130(2014)13—1734—03ApplicationvalueofprocalcitoninquantitativedetectionindiagnosisofpediatricbloodstreaminfectionHuangYanxin,JiangChaoxin,XianJieneng,YahWen(DepartmentoJ’ClinicalLaboratory,NanhaiDistrictThirdPeopleSHospital,F(xiàn)oshan,Guangdong528244,China)Abstract:ObjectiveT
4、oexploretheapplicationvalueofserumprocalcitonin(PCT)quantitativedetectionindiagnosingpediat—ricbloodstreaminfection.MethodsTheresultsof183casesofbloodcultureandsimultaneousPCTdetectioninahospitalfromFebruarytoNovember2013wereanalyzedretrospectively.Thepatientsweredividedintothenon-bloo
5、dstreaminfectiongroupandthebloodstreaminfectiongroupaccordingtothebloodcultureresultsasthegoldenstandard.ThedifferencesofserumPCTconeen—trationwerecomparedbetweenthetwogroupsbytheMann-WhitneyUtest.ResultsTheserumPCTconcentrationwas0.15(0.065—0.55)ng/mIinthenon—bloodstreaminfectiongroup
6、and1.11(O.505—8.975)ng/mIinthebloodstreaminfectiongroup,thedifferencewasstatisticallysignificant(P=0.000);with0.50ng/mLasthecut—offvalueofdiagnosis,thesensitivityandthespe—cificityofPCTwas77.8and73.3respectively,thepositiveandpegativepredictivevalueofPCTwas24.1and96.8re—spectively.Conc
7、lusionThequantitativedetectionofPCTcanassistinrapidlydiagnosingorexcludingbloodstreaminfectionandprovidesreferenceforavoidingtheoveruseofantibioticsorconductingtheearlyanti—infectiontherapy.Keywords:procalcitonin;bloodstreaminfection;diagnosis血流感染為全身感染性疾病,血培養(yǎng)一直是診斷血流感染格無(wú)菌操作采集標(biāo)本后立即注入血培