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1、論著·2014年1月第4卷第1期子癇前期子宮螺旋動脈血流與孕婦血清胎盤生長因子表達的相關研究李哲韓清劉彩娥。王英華1.山西醫(yī)科大學,山西太原030001;2.太原市婦幼保健院,山西太原030013;3.山西醫(yī)科大學第一醫(yī)院婦產(chǎn)科,山西太原030001【摘要】目的觀察子宮螺旋動脈血流動力學參數(shù)與孕婦血清中胎盤生長因子(PLGF)含量,兩者結(jié)合分析子癇前期的嚴重程度。方法對30例初診子癇前期孕婦及154名健康孕婦,通過彩色多普勒超聲技術(shù)(CDFI)檢測子宮螺旋動脈血流動力學參數(shù):搏動指數(shù)(PI)值、阻力指數(shù)(RI)值、收縮期峰值流速與舒張末期血流速度之比值(S/Do使用酶聯(lián)免疫吸附試驗(EL
2、ISA)法測定孕婦血清中PLGF的含量。結(jié)果(1)子癇前期組的PI值、RI值、S/D值較對照組有所增高,差異有統(tǒng)計學意義(P<0.01)。子癇前期重度組較輕度組的值增高,差異有統(tǒng)計學意義(P<0.001)。(2)子癇前期組的血清PLGF含量較對照組降低,差異有統(tǒng)計學意義(P<0.001),子癇前期重度組低于輕度組,差異有統(tǒng)計學意義(P<0.001o(3)子癇前期血清PLGF分別與PI(r一0.55,P<0.05)、RI(,.一0.58,P<0.05)、S/D(r=一0.62,P<0.05),呈顯著負相關。結(jié)論(1)彩色多普勒超聲技術(shù)檢測子宮螺旋動脈血流、孕婦血清PLGF含量都與子癇前期嚴
3、重程度相關。(2)子宮螺旋動脈血流動力學參數(shù)與子癇前期孕婦血清PLGF表達之間呈顯著負相關?!娟P鍵詞]子癇;超聲學;血清胎盤生長因子.【中圖分類號】R714.2【文獻標識碼】A【文章編號】2095—0616(2014)O1—18一O4CorrelationbetweenhemodynamicsofuteriHespiralarteryandq)SnofserumvascularplacentagrowthfactorinpregnantwomenL/ZheHANQing‘LIUCaiWANGringhu~1.ShanxiMedicalUniversity,Taiyuan030001,Ch
4、ina;2.TaiyuanHospitalHealthCenterforWomenandChildren,Taiyuan030013,China;3.DepartmentofGynaecologyandObstetrics,No.1HosipitalofShanxiMedicalUniversity,Taiyuan030001,China[Abstract]ObjectiveToanalyzethecorrelationbetweenalteredhemodynamicsofuterinespiralarteryandseverityofpre-eclampsiaduringpregna
5、ncybycolorDopplerultrasounddetectionofuterinespiralarteryandtestofserumavscularplacentagrowthfactor(PLGF).MethodsBeforepharmacotherapy,theuterinespiralarterywasmeasuredwithcolorDopplerultrasoundin30casesofpre-eclampsiacomplicatingpregnancyand154casesofnormalpregnancy.Theresultswererecordedandcomp
6、aredbetweenthetwogroups.ELISAwasusedfordetectingserumPLGFinallsubjects.Results(1)Oftheuterinespiralarteryhemodynamicparameters,PI,RIandS/Dwerehigherinpre-eclampsiagroupthaninnormalgroupfP<0.O1).Thesehemodynamicparameterswerehigherinpatientswithseverepre-eclampsiathaninmildcases<0.001).(2)Theconte
7、ntsofserumPLGFwaslowerinpre-eclampsiagroupthaninnormalgroup(P<0.001).a(chǎn)ndinseverepre-eclampsiagroupandinmildcases(P