子癇前期患者可溶性血管內(nèi)皮生長(zhǎng)因子及其受體與子宮胎盤床螺旋動(dòng)脈變化及意義

《子癇前期患者可溶性血管內(nèi)皮生長(zhǎng)因子及其受體與子宮胎盤床螺旋動(dòng)脈變化及意義》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫(kù)。

1、子癇前期患者可溶性血管內(nèi)皮生長(zhǎng)因子及其受體與子宮胎盤床螺旋動(dòng)脈變化及意義作者：楊俊紅,曹淑新,梁學(xué)軍,劉志奇單位：河北省唐山市婦幼保健院婦產(chǎn)科(楊俊紅、曹淑新)；河北省灤縣中醫(yī)院婦產(chǎn)科(梁學(xué)軍)；河北省石家莊市中心醫(yī)院麻醉科(劉志奇)【摘要】目的研究可溶性血管內(nèi)皮生長(zhǎng)因子受體1(sFlt1)和血管內(nèi)皮生長(zhǎng)因子(VEGF)在子癇前期患者血清中的濃度變化,以及子宮胎盤床螺旋動(dòng)脈的相應(yīng)變化,探討sFlt1和VEGF在子癇前期中的作用。方法采用酶聯(lián)免疫吸附試驗(yàn)(ELISA)分別測(cè)定輕度子癇前期、重度子癇前期患者及正

2、常妊娠婦女外周血清中sFlt1和VEGF的濃度。同時(shí)按照Robertson方法,獲取胎盤床活檢標(biāo)本,在光學(xué)顯微鏡下觀察子癇前期組與對(duì)照組胎盤床螺旋動(dòng)脈的生理性變化。結(jié)果(1)子癇前期組各組外周血清中sFlt1水平明顯高于對(duì)照組(P0.01),子癇前期重度組高于子癇前期輕度組(P0.05);(2)子癇前期組各組外周血血清中VEGF水平明顯低于對(duì)照組(P0.05),子癇前期重度組低于子癇前期輕度組(P0.05)。正常妊娠組與子癇前期組胎盤床蛻膜螺旋動(dòng)脈的生理性改變差異無(wú)統(tǒng)計(jì)學(xué)意義(P＞0.05)。子癇前期組肌層

3、螺旋動(dòng)脈的生理性改變明顯少于正常妊娠組，2組差別有統(tǒng)計(jì)學(xué)意義(P＜0.05)。結(jié)論外周血中升高的sFlt1和降低的VEGF以及相應(yīng)的肌層螺旋動(dòng)脈生理性改變可能與妊娠期高血壓的發(fā)病有關(guān),并參與了子癇前期病理生理過程?！娟P(guān)鍵詞】子癇前期可溶性血管內(nèi)皮生長(zhǎng)因子受體1血管內(nèi)皮生長(zhǎng)因子胎盤床螺旋動(dòng)脈　　Alterationandpotentialroleofsolublefmsliketyrosinekinasereceptor1andthealterationoftheplacentalbedspiralarter

4、iesinpreeclampsia　　YANGJunhong，CAOShuxin,LIANGXuejun,etal.　　DepartmentofGynecologyandObstetrics,MaternalandChildHealthHospitalofTangshan,Hebei,Tangshan063000　【Abstract】ObjectiveToinvestigatethealterationofserumvascularendothelialgrowthfactorandsolublefmsl

5、iketyrosinekinasereceptor1(sFlt1)inpatientswithpreeclampsia.AndthecorrelationoftheplacentalbedspiralarteriesandtheroleroleofsFlt1andVEGFpreeclampisapathophysiology.MethodsSerumvascularendothelialgrowthfactorandsolublefmsliketyrosinekinasereceptor1inperiph

6、eralvenousbloodweredeterminedbyELISAinpatientswithpreeclampsia,severepreeclampsiaandhealthycontrols.AccordingtotheRobertson’smethods,theplacentalbedwasobtainedbybiopsies.Thephysiologicalchangesofspiralarterieswerecomparativelystudiedwithlightmicroscope

7、.ResultsPatientswithpreeclampsiahadhigherlevelofserumsFlt1andlowerserumlevelofVEGFthanthatincontrolgroup(P＜0.01).Therewerenosignificantdifferencesbetweennormalpregnanceisandpreeclampsiapatientsinphysiologicalchangesofdeciduassegmentsofspiralarteries(P0.05).

8、Thephysiologicalchangesofmyometriumspiralarteriesinpreeclampsiaweremarkedlylessthanthatinnormalpregnanoy(P0.05).ConclusionThehappeningofpreeclampsiawasrelatedcloselytothedecreaseofphysiologicalc