兔橈骨臨界骨缺損模型的制備_周芳

兔橈骨臨界骨缺損模型的制備_周芳

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時(shí)間:2017-12-10

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1、中國(guó)組織工程研究與臨床康復(fù)第15卷第50期2011–12–10出版JournalofClinicalRehabilitativeTissueEngineeringResearchDecember10,2011Vol.15,No.50兔橈骨臨界骨缺損模型的制備*☆◆11222周芳,李靜,余磊,廖華,歐陽(yáng)鈞Establishmentofaradialbonecriticaldefectmodelinarabbit11222ZhouFang,LiJing,YuLei,LiaoHua,OuyangJunAbstract1BACKGROUND:Nonunio

2、ncausedbyvariousreasonsoffracturesandbonedefectshasbeenamajorproblemofclinicalSouthernMedicalorthopedicrehabilitation.Withtherapiddevelopmentoftissueengineering,productqualitytestingneedsstandardbonedefectUniversity,Guangzhoumodel.However,thelengthofbonecritical-sizedefectshas

3、notbeenascertained.510515,GuangdongOBJECTIVE:Toestablishrabbitradialbonedefectmodelsandtodeterminethelengthofrabbitradialbonecritical-sizedefects.Province,China;2METHODS:EighteenmaleNewZealandwhiterabbits(2.0-2.5kg)wererandomlyassignedinto6groupsandthen12,13,14,15,Departmentof

4、16and17mmsegmentaldefectswerecreatedinthemiddlepartofradiusonbothsides,respectively.TheincisionswereHumanAnatomy,SouthernMedicalsuturedandbandaged,butnotfixed.University,RESULTSANDCONCLUSION:AccordingtoexaminationwithnakedeyesandX-ray,someofthesegmentaldefectswiththeGuangdongl

5、engthof12,13,14,15and16mmwerecompletelyrepaired.Butnoneofthedefectswiththelengthof17mmwasrepaired.ProvincialKeyHistologicalexaminationshowedthattherewastrabecularboneformation,bonematrix,medullarycavityrecanalization,LaboratoryofTissueConstructionandrevascularizationandosteobl

6、astsinthesegmentaldefectswiththelengthof12,13,14,15and16mm.However,therewereInspection,osteoblasts,osteoclastsinthe17mmdefects,butnomedullarycavityrecanalizationorrevascularization.Therefore,thelengthGuangzhou510515,ofbonecritical-sizedefectinrabbitradiuswas17mm.GuangdongProvi

7、nce,ChinaZhouF,LiJ,YuL,LiaoH,OuyangJ.Establishmentofaradialbonecriticaldefectmodelinarabbit.ZhongguoZuzhiGongchengZhouFang☆,YanjiuyuLinchuangKangfu.2011;15(50):9385-9388.[http://www.crter.cnhttp://en.zglckf.com]Studyingfordoctorate,SouthernMedicalUniversity,摘要Guangzhou510515,G

8、uangdongProvince,背景:各種原因造成的骨折和骨缺損導(dǎo)致的骨不連一直是臨床骨科修復(fù)的一大難題,相關(guān)產(chǎn)品質(zhì)量的

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