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《全身聯(lián)合鼓膜置管鼓室給予地塞米松治療重度特發(fā)性突聾的療效分析》由會員上傳分享,免費在線閱讀,更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、第44卷第3期第339頁華中科技大學學報(醫(yī)學版)V01.44No.3P.3392015年6月ActaMedUnivSciTechnolHuazhongJun.2O15全身聯(lián)合鼓膜置管鼓室給予地塞米松治療重度特發(fā)性突聾的療效分析鄭燁賢,彭利艷,崔永華,劉愛國△華中科技大學同濟醫(yī)學院附屬同濟醫(yī)院耳鼻咽喉一頭頸外科,武漢430030摘要:目的分析鼓膜置管后鼓室給予地塞米松聯(lián)合全身激素治療重度特發(fā)性突聾的效果和影響其預(yù)后的因素。方法回顧性分析49例重度特發(fā)性突聾患者臨床資料。49例重度特發(fā)性突聾患者依治療方式分為2組:A組,29例,接受全身激素治療;B組,2o例,接受鼓膜置管鼓室
2、給予地塞米松聯(lián)合全身激素治療。兩組在發(fā)病年齡、性別、患耳、伴隨耳鳴或眩暈癥狀等均經(jīng)良好配對。比較兩種治療方法的療效,并分析伴隨耳鳴和眩暈癥。狀對預(yù)后的影響。結(jié)果A組治療總有效率為69.0(20/29),痊愈率為6.9(2/29),B組總有效率為70.0(14/20),痊愈率為15.0(3/20),兩組總有效率經(jīng)卡方檢驗差異無統(tǒng)計學意義(P一0.938)。耳鳴或眩暈癥狀對治療效果沒有顯著影響(均P>0.05)。治療后各頻率平均聽閾改善經(jīng)ANOVA分析顯示,差異亦無統(tǒng)計學意義。結(jié)論在重度特發(fā)性突聾患者的治療中,全身聯(lián)合鼓膜置管鼓室給予地塞米松治療與單純?nèi)斫o藥的療效相比沒有明顯
3、差異。耳鳴或眩暈等伴隨癥狀對重度特發(fā)性突聾患者的預(yù)后無明顯影響。關(guān)鍵詞:鼓膜置管;鼓室給藥;糖皮質(zhì)激素;特發(fā)性突聾中圖分類號:R764.437DOI:10.3870/j.issn.1672—0741_2O15.03.022EfficacyofCombinationTherapywithIntratympanicandSystemicDexamthasoneforTreatmentofPatientswithSevere-to-ProfoundIdiopathicSuddenSens0rineuralHearingLossZhengYexian,PengLiyan,CuiYo
4、nghuaetalDepartmentofOtorhinolaryngologyHeadandNeckSurgery,TongJiHospital,TongJiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,ChinaAbstractObjectiveToexaminethetherapeuticefficacyofcombinationtherapywithintratympanicandsystemicdexamthasoneforthetreatmentofpatientswith
5、severe—to—profoundidiopathicsuddensensorineura1hearinglOSS(ISSNHL)andtheprognosticfactorsofthisdisease.MethodsClinicaldataof49severe—to—profoundpatientswithISSNHLwereretrospectivelyanalyzed.Thesepatientsweredividedintotwogroupsintermsofdifferenttherapeuticstrategies:groupA,inwhich29patient
6、sreceivedthesystemichigh-dosedexamethasonetaperingtherapy;groupB,inwhich,20patientsweregivennotonlysystemichigh—dosedexamesthasonetaperingtherapybutalsothetrans—tympanicdexamethasonetherapy.Patientsinbothgroupswerewellmatchedforage,sex,affectedpart,initialpuretoneaverage(PTA),dizziness,and
7、tinnitus.Thecurativeeffectwascomparedbetweenthetwogroupsandtheinfluenceofaccompanyingtinnitusanddizzinesswasanalyzedonprognosis.ResultsThetotaleffectiveratewas69.0(20/29)ingroupAand70.0(14/20)ingroupB.Therecoveryratewas6.9(2/29)ingroupAand15.0%(3/20)ingroupB.C