資源描述：
《Notch家族蛋白、LCHAD在早發(fā)型重度子癇前期患者胎盤組織中的表達及意義.pdf》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、臨京醫(yī)學(xué)工程2014年6月第21卷第6期·699··論著·(實驗研究)Notch家族蛋白、LCHAD在早發(fā)型重度子癇前期患者胎盤組織中的表達及意義趙莉娜，馬瑞霞，劉國成(廣東省婦幼保健院，廣東廣州510010)【摘要】目的探討Notch家族蛋白、長鏈三羥基?；o酶A脫氫酶(LCHAD)的表達與早發(fā)型重度子癇前期發(fā)病的關(guān)系，揭示早發(fā)型重度子癇前期發(fā)病機理方法選擇早發(fā)型重度子癇前期患者45例、晚發(fā)型重度子癇前期患者42例為研究組，40例正常分娩者為對照組．免疫組化法檢測Notch家族蛋白、LCHAD在胎盤絨毛組織中的分布和表達水平。結(jié)果各組胎盤組織的合體滋養(yǎng)細
2、胞、血管內(nèi)皮細胞、蛻膜細胞中均可以檢測到Notch家族蛋白、LCHAD的表達。早發(fā)型重度子癰前期組Notch家族蛋白、LCHAD表達均顯著低于晚發(fā)型重度子癇前期組及對照組。各組胎盤組織中Notch家族蛋白表達與LCHAD表達水平呈正相關(guān)。結(jié)論早發(fā)型重度子癇前期組胎盤中Notch家族蛋白、LCHAD低表達與疾病的發(fā)病發(fā)展密切相關(guān)。二者通過影響滋養(yǎng)細胞浸潤．胎盤淺著床在早發(fā)型重度子癇前期發(fā)生發(fā)展中起重要作用?！娟P(guān)鍵詞】早發(fā)型重度子癇前期；Notch家族蛋白；長鏈三羥基?；o酶A脫氫酶中圖分類號：R714．245文獻標識碼：Adoi：10．39690．issn．
3、1674—4659．2014．06．0699ExpressionLevelsandC。linicalValuesofNotchProteinsandLCHADinthePlacentaofEarly—onsetSeverePreeclampsiaZHA0Lina,MARuixia,LIUGuochengrGuangdongWomenandChildrenHospital,Guangzhou510010,China)【Abstract】ObjectiveTostudytherelationshipbetweenNotchproteinsandLCHADand
4、early—onsetseverepreeclampsia，andtorevealthepathogenesisofthedisease．Methods45early—onsetseverepreeclampsiaand42late—onsetpatientswereselectedasastudygroup，and40patientswithnormaldeliverieswereselectedasacontrolgroup．WedetectedthedistributionandexpressionlevelsoftheNotchproteinsan
5、dLCHADinplacentalvilluswithanimmunohistochemicalmethod．ResultsTheNotchproteinsandLCHADcouldbedetectedinsyncytiotrophoblasts，vascularendothelialcellsanddecidualcellsoftheplacenta．TheexpressionlevelsoftheNotchproteinsandLCHADintheearly-onsetpatientsweresignificantlylowerthanthoseint
6、helate—onsetpatientsandthoseinthecontrolgroup．TheexpressionlevelsofNotchproteinshadapositivecorrelationwiththoseofLCHAD．ConclusionsTheearly—onsetseverepreeclampsiaiscloselyrelatedtothelowexpressionlevelsofNotchproteinsandLCHAD，whichplayanimportantroleduringtheshallowimplantationof
7、theplacentabyinfluencingtheinfiltrationoftrophocytesandtheonsetandprogressionofearly—onsetseverepreeclampsia．【Keywords】Earlyonsetseverepreeclampsia；Notchfamilyproteins；Long—chain3hyroxyacylacyl—COAdehydrogenase(LCHAD)早發(fā)型重度子癇前期患者發(fā)病早、病情重，比晚發(fā)型者有1．2試驗方法著嚴重的圍產(chǎn)和產(chǎn)科結(jié)局，其發(fā)病機制至今不清，目前滋養(yǎng)細1．2．1
8、標本制備無菌剪取胎盤臍帶根部附著區(qū)母體面中央1．5胞淺著床學(xué)說成為
