資源描述:
《幽門螺桿菌感染與非酒精性脂肪肝相關(guān)性研究-論文.pdf》由會員上傳分享,免費在線閱讀,更多相關(guān)內(nèi)容在應(yīng)用文檔-天天文庫。
1、醫(yī)學(xué)研究雜志2014年6月第43卷第6期·論善·幽門螺桿菌感染與非酒精性脂肪肝相關(guān)性研究彭朝陽盛曉燕丁海燕彭朝勝摘要目的探討幽門螺桿菌(Helicobacterpylori,Hp)感染與非酒精性脂肪肝(nonalcoholicfattyliverdisease,NAFLD)的關(guān)系。方法選取筆者醫(yī)院2009年2月~2013年l0月門診及住院的受試者共250例分為兩組,非酒精性脂肪肝組(A組)150例及健康對照組(B組)100例,通過”c一尿素呼氣試驗(”C—ureabreathtest,”C—UBT)
2、檢測受試者”c同位素豐度,根據(jù)其結(jié)果計算超基準(zhǔn)值(deltaoverbaseline,DOB),判斷其Hp感染情況。同時測定胰島素、高敏C反應(yīng)蛋白(high—sensitivityC—reac—tiveprotein,hs—CRP)、血脂系列,計算胰島素抵抗指數(shù)(insulinresistanceindex,IRI),并對相關(guān)數(shù)據(jù)進(jìn)行對比分析。結(jié)果兩組Hp總感染率為57.6%,NAFLD組Hp感染率為68.7%,明顯高于對照組41%(P<0.01);脂肪肝組DOB值,hs—CRP,IRI明顯高于對照
3、組(P<0.O1),其中DOB值與hs—CRP,IRI呈正相關(guān);Logistic多元回歸分析顯示,DOB值、IRI、hs—CRP、甘油三酯(TG)與NAFLD密切相關(guān)。結(jié)論Hp感染是NAFLD的危險因子,其與胰島素抵抗及hs—CRP密切相關(guān)。關(guān)鍵詞幽門螺桿菌感染非酒精性脂肪肝胰島素抵抗高敏C反應(yīng)蛋白c一尿素呼氣試驗[中圖分類號]R575[文獻(xiàn)標(biāo)識碼]ARelationshipbetweenHelicobacterPyloriInfectionandNonalcoholicFattyLiverDise
4、ase.PengChaoyang,ShengXiaoyan,DingHaiyan,ela1.DepartmentofClinicalMedicine,Nanchang334hospital,Jiangxi330024,ChinaAbstract0bjectiveToinvestigatetherelationshipbetweenhelicobacterpyloriinfectionandnonalcoholicfattyliverdisease.MethodsThesurveywasconduct
5、edin250subjectsselectedfromourhospitalbetweenFebruary2009andOct2013.Basedonthediag—nosticcriteriaofNAFLD,thesubjectsweredividedintotwogroups:NAFLDgroup(n=150),normalcontrolgroup(n=100).Thelev—elof。Cabundancewasmeasuredby¨C—ureabreathtest.Thedeltaoverba
6、selinewascalcalated.TheHPinfectionwasdeterminedacocordingtotheDOB.Thelevelofseluminsulin,high—sensitivityc—reactiveprotein,bloodlipidseriesandtheinsulinresistanceindexwerealsodetermined.Thentherelateddatawereanalyzed.ResultsThetotalHpinfectionrateoftwo
7、groupswas57.6%.TheHpin—fectionrateofNAFLDgroupwas68.7%.Itwasobviouslyhigherthanthatofcontrolgroup(P<0.01).IntheNAFLDgroup,theDOBvalue,hs—CRPandIR1weresignificantlyhigher(P<0.01).Thelevelofhs—CRPandIR1werepositivelycorrelatedwithDOBvalue(r=0.422,0.363,a
8、UP<0.05).LogisticregressionanalysisshowedthatthelevelofDOBvalue,IRI,hs—CRP,triglycerideswerecloselyassociatedwiththeNAFLD.ConclusionTheHpinfectionwasoneoftheriskfactorsforNAFLD.Itwascloselyassociatedwiththehs—CRPandinsulinresistance.Key