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1、醫(yī)學(xué)研究雜志2014年6月第43卷第6期·論善·幽門螺桿菌感染與非酒精性脂肪肝相關(guān)性研究彭朝陽盛曉燕丁海燕彭朝勝摘要目的探討幽門螺桿菌(Helicobacterpylori，Hp)感染與非酒精性脂肪肝(nonalcoholicfattyliverdisease，NAFLD)的關(guān)系。方法選取筆者醫(yī)院2009年2月～2013年l0月門診及住院的受試者共250例分為兩組，非酒精性脂肪肝組(A組)150例及健康對照組(B組)100例，通過”c一尿素呼氣試驗(”C—ureabreathtest，”C—UBT)
2、檢測受試者”c同位素豐度，根據(jù)其結(jié)果計算超基準(zhǔn)值(deltaoverbaseline，DOB)，判斷其Hp感染情況。同時測定胰島素、高敏C反應(yīng)蛋白(high—sensitivityC—reac—tiveprotein，hs—CRP)、血脂系列，計算胰島素抵抗指數(shù)(insulinresistanceindex，IRI)，并對相關(guān)數(shù)據(jù)進(jìn)行對比分析。結(jié)果兩組Hp總感染率為57．6％，NAFLD組Hp感染率為68．7％，明顯高于對照組41％(P<0．01)；脂肪肝組DOB值，hs—CRP，IRI明顯高于對照
3、組(P<0．O1)，其中DOB值與hs—CRP，IRI呈正相關(guān)；Logistic多元回歸分析顯示，DOB值、IRI、hs—CRP、甘油三酯(TG)與NAFLD密切相關(guān)。結(jié)論Hp感染是NAFLD的危險因子，其與胰島素抵抗及hs—CRP密切相關(guān)。關(guān)鍵詞幽門螺桿菌感染非酒精性脂肪肝胰島素抵抗高敏C反應(yīng)蛋白c一尿素呼氣試驗[中圖分類號]R575[文獻(xiàn)標(biāo)識碼]ARelationshipbetweenHelicobacterPyloriInfectionandNonalcoholicFattyLiverDise
4、ase．PengChaoyang，ShengXiaoyan，DingHaiyan，ela1．DepartmentofClinicalMedicine，Nanchang334hospital，Jiangxi330024，ChinaAbstract0bjectiveToinvestigatetherelationshipbetweenhelicobacterpyloriinfectionandnonalcoholicfattyliverdisease．MethodsThesurveywasconduct
5、edin250subjectsselectedfromourhospitalbetweenFebruary2009andOct2013．Basedonthediag—nosticcriteriaofNAFLD，thesubjectsweredividedintotwogroups：NAFLDgroup(n=150)，normalcontrolgroup(n=100)．Thelev—elof。Cabundancewasmeasuredby¨C—ureabreathtest．Thedeltaoverba
6、selinewascalcalated．TheHPinfectionwasdeterminedacocordingtotheDOB．Thelevelofseluminsulin，high—sensitivityc—reactiveprotein，bloodlipidseriesandtheinsulinresistanceindexwerealsodetermined．Thentherelateddatawereanalyzed．ResultsThetotalHpinfectionrateoftwo
7、groupswas57．6％．TheHpin—fectionrateofNAFLDgroupwas68．7％．Itwasobviouslyhigherthanthatofcontrolgroup(P<0．01)．IntheNAFLDgroup，theDOBvalue，hs—CRPandIR1weresignificantlyhigher(P<0．01)．Thelevelofhs—CRPandIR1werepositivelycorrelatedwithDOBvalue(r=0．422，0．363，a
8、UP<0．05)．LogisticregressionanalysisshowedthatthelevelofDOBvalue，IRI，hs—CRP，triglycerideswerecloselyassociatedwiththeNAFLD．ConclusionTheHpinfectionwasoneoftheriskfactorsforNAFLD．Itwascloselyassociatedwiththehs—CRPandinsulinresistance．Key
