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1、中國(guó)當(dāng)代醫(yī)藥2014年9月第2l卷第25期·藥物與臨床·抗病毒治療乙型肝炎相關(guān)慢加急性肝衰竭的效果分析許飛姜蔓蕾曾敬科胡江玲梁斌江西省贛州市第五人民醫(yī)院肝病科，江西贛州341000【摘要】目的研究抗病毒治療乙型肝炎相關(guān)慢加急性肝衰竭患者的效果。方法選擇2011年5月～2013年11月在本院接受治療的乙型肝炎相關(guān)慢加急性肝衰竭患者92例，將其隨機(jī)分成對(duì)照組和觀察組，各46例。對(duì)照組給予乙型肝炎相關(guān)慢加急性肝衰竭的常規(guī)內(nèi)科治療，觀察組在對(duì)照組基礎(chǔ)上聯(lián)合拉米夫定進(jìn)行抗病毒治療，觀察治療前后患者肝功能指標(biāo)的變化，同時(shí)比較兩組患
2、者的好轉(zhuǎn)率和存活率。結(jié)果治療后，兩組的Alb、A水平升高，TBiL、AST水平下降，且觀察組上述指標(biāo)的改善情況優(yōu)于對(duì)照組(尸<0．05)；觀察組的好轉(zhuǎn)率、存活率分別為54．3％、60．9％，高于對(duì)照組的39．1％、37．0％(P<0．05)。結(jié)論常規(guī)內(nèi)科治療乙型肝炎相關(guān)慢加急性肝衰竭同時(shí)聯(lián)合抗病毒治療能顯著改善患者的肝功能、提高患者的存活率，臨床應(yīng)用價(jià)值顯著，值得推廣?！娟P(guān)鍵詞】乙型肝炎；慢加急性肝衰竭；抗病毒；肝功能；存活率【中圖分類號(hào)】R512．6f文獻(xiàn)標(biāo)識(shí)碼】Af文章編號(hào)】1674—4721(2014)09(a)
3、一0105—03EfectanalysisofantivirustreatinghepatitisBrelatedchronic-and-acuteliverfailureXUFeiJIANGMan-leiZENGJing-keHUJiang-lingLIANGBinDepartmentofLiverDisease，TheFifthPeopleSHospitalofGanzhouCityinJiangxiProvince，Ganzhou341000，China[Abstract]ObjectiveToexploreth
4、eeffectsofantivirustreatinghepatitisBrelatedchronic-and-acuteliverfailure．Methods92patientwithhepatitisBrelatedchronic-and—acuteliverfailuretreatedinourhospitalfromMay2011toNovember2013wereselected，andtheywererandomlydividedintothecontrolgroupandtheobservationgr
5、oup，with46patientsineachgroup．ThecontrolgroupwastreatedwiththeregulartreatmentofhepatitisBrelatedchronic-and-a—cuteliverfailure，andtheobservationgroupwastreatedwiththeantiviraltherapyoflamivudine．Changesofindicesofliverfunctionbeforeandaftertreatmentwereobserved
6、，andimprovementrateandsurvivalratebetweenthetwogroupswerecompared．ResultsAftertreatment，levelsofAlb，PTAwasincreased，andlevelsofTBiL，ASTwasdecreasedandtheimprovingdegreeoftheabove-mentionedindicesintheobservationgroupwasbetterthanthatinthecontrolgroupfP<0．05)；rec
7、overyrateandsurvivalrateintheobservationgroup(54．3％and60．9％respectively)werehigherthanthoseofthecontrolgroup(39．1％and37．0％respectively)(P<0．05)．ConclusionRegulartreatmentofhepatitisBrelatedchron—ic-and-acuteliverfailurecombinedwithantiviraltherapycansignificantl
8、yimproveliverfunctionsofpatientsandin—creasesurvivalrateofpatients，whichisofgreatclinicalvalueandisworthyofpromotion．【Keywords]HepatitisB；Chronic-and-aeuteliverfailur
