降鈣素原和N末端前體腦鈉肽對(duì)膿毒血癥預(yù)后評(píng)估意義的研究-論文.pdf

《降鈣素原和N末端前體腦鈉肽對(duì)膿毒血癥預(yù)后評(píng)估意義的研究-論文.pdf》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。

1、·48·中華臨床醫(yī)師雜志r電子版)2014年5月第8卷第lO期chilIJClinicians(E1~ctronicEdition)．Mas'15。2014，v01．8'N0．Q·臨床論著●降鈣素原和N末端前體腦鈉肽對(duì)膿毒血癥預(yù)后評(píng)估意義的研究郭少卿鄒原方【摘要】目的探討血清降鈣素原(PCT)和N末端前體腦鈉肽(NT-proBNP)對(duì)膿毒血癥預(yù)后評(píng)估的臨床意義。方法72例膿毒血癥患者按預(yù)后分為存活組和死亡組，比較發(fā)病早期PCT、NT-proBNP及急性生理與慢性健康狀況(APACHEII)評(píng)分，并建立ROC曲線觀察兩種標(biāo)記物對(duì)預(yù)后評(píng)估的臨床價(jià)值。結(jié)果PCT、NT-proBNP和A

2、PACHEII評(píng)分兩組患者中均有統(tǒng)計(jì)學(xué)差異(P

3、procalcitoninandn-terminalprobrainnatriureticpeptideinpatientswithsepsisGuoShaoqing',ZouYuanfang．"DepartmentofEmergency,TheAfiliatedDonghuaHospitalofSunYet-SenUniversity,Dongguan523220,ChinaCorrespondingauthor：ZouYuanfang,Email：zouyuanfang2008@163．corn[Abstract]0bjectiveToevaluatetheprognosti

4、cvalueofprocalcitonin(PCT)andN-temfinalprobrainnatriureticpeptide(NT-proBNP)．MethodsSeventy·twopatientswi廿lsepsisweredividedintosurvivalgroupanddeathgroupaccordingtotheiroutcome．LevelsofPCTandNT．proBNPweremeasuredintheearlystageoftreatment，andAPACHEI1werescored．ROCwasconstructedtoobservethepr

5、ognosticvalueofthebiomarkers．ResultsThereweresignificantdiferencesinlevelsofbothbiomarkersandAPACHEIIscorebetweengroups，andbothwereobviouslycorrelatedwithAPACHEIIscore．Theareaunderthecurve(AUC)ofPCTandNT-proBNPwere0．822andO．843，respectively．ThesensibilityandspecificityofPCTwere78-3％and71．4％．w

6、hilethesensibilityandspecificityofNT-proBNPwere82．6％and85．7％．NT-proBNPwasbeRerthanPCTinevaluatingprognosisofsepsis．ThespecificitywashigherwhenPCTandNT-proBNPwerecombinedtoevaluateprognosis(90．O％、．ConclusionPCTandNT-proBNParebothgoodbiomarkersforevaluatingpatients’prognosis，andcombinedevaluati

7、onCanincreasethespecificity．[Keywords]Sepsis；Procalcitonin；N—terminalprobrainnatriureticpeptide重癥監(jiān)護(hù)病房(ICU)和急診重癥監(jiān)護(hù)病房肽(N—terminalprobrainnalriureticpeptide，(EICU)中膿毒血癥的發(fā)生率為l1％---15％，死亡NT-proBNP)均可在嚴(yán)重膿毒血癥時(shí)出現(xiàn)異常升高，率高達(dá)30％以上早期對(duì)膿毒血癥進(jìn)行預(yù)測(cè)，以對(duì)膿毒血癥的診斷有明確意