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1、遼寧中醫(yī)雜志2013年第40卷第10期·2155·萎胃康顆粒逆轉(zhuǎn)慢性萎縮性胃炎的p53機(jī)制研究12程艷，趙巖(1．濱州市人民醫(yī)院，山東濱州256603;2．濱州醫(yī)學(xué)院，山東煙臺(tái)264003)摘要:目的:探討萎胃康顆粒逆轉(zhuǎn)慢性萎縮性胃炎(CAG)的機(jī)制。方法:將90只SD大鼠隨機(jī)抽取18只為正常對(duì)照組(正常組)，其余72只采用多重刺激6周復(fù)制大鼠CAG模型。確定造模成功的64只隨機(jī)分為4組，即模型對(duì)照組、萎胃康大劑量組、萎胃康小劑量組、三九胃泰組，分別ig生理鹽水、萎胃康高濃度水煎液、萎胃康低濃度水煎液和三九胃泰混懸液，1次/d。給藥30d后，觀察對(duì)大鼠胃黏膜
2、組織形態(tài)及突變型p53表達(dá)的影響。結(jié)果:模型組大鼠胃黏膜病理無明顯改善，突變型p53表達(dá)較正常組顯著升高(P＜0．01);各治療藥物均可顯著改善胃黏膜萎縮，降低胃黏膜突變型p53表達(dá)，較模型組具有顯著性差異(P＜0．01)。其中以萎胃康大劑量組大鼠胃黏膜p53的平均光密度最低，較其他治療組有顯著性差異(P＜0．01)。結(jié)論:萎胃康能改善和逆轉(zhuǎn)實(shí)驗(yàn)性萎縮性胃炎大鼠胃黏膜萎縮，其療效與劑量有關(guān)，其機(jī)制可能與抑制細(xì)胞的異常增殖有關(guān)。關(guān)鍵詞:萎胃康;萎縮性胃炎;p53中圖分類號(hào):R573．32文獻(xiàn)標(biāo)志碼:B文章編號(hào):1000－1719(2013)10－2155－02
3、Researchonp53MechanismofWeiweikangReversingChronicAtrophicGastritis12CHENGYan，ZHAOYan(1．BinzhouPeople＇sHospital，Binzhou256603，Shandong，China;2．BinzhouMedicalUniversity，Yantai264003，Shandong，China)Abstract:Objective:TodiscussthemechanismofWeiweikangreversingchronicatrophicgastritis．
4、Methods:18ratsfrom70SDratswererandomlyselectedoutasnormalcontrolgroup(normalgroup)．Theremaining72ratsweremadeCAGmodelwiththemultiplestimulationsfor6weeks．Theremaining64ratswhichweremodeledsuccessfullywererandomlydividedintofourgroupssuchasmodelgroup，Weiweikanglargedosegroup，Weiweik
5、angsmalldosegroupandSanjiuWeitaigroup．Thegroupswereinjected0．9%saline，Weiweikanghighpotencydecoction，WeiweikanglowpotencydecoctionandSanjiuWeitaisuspension，onceaday．After30days，thegastricmucosapathologicalchangesandtheexpressionofmutantp53wereobserved．Results:Therewasnosignificantd
6、ifferentiationofgastricmucosapathematologyinmodelgroup．Theexpressionofmutantp53madeasignificantincreasecomparedwithmodelgroup(P＜0．01)．Thetherapeuticdrugsallcouldsignificantlyimprovegastricmucosaatrophyandreducetheexpressionofthemutantp53andcomparedwiththemodelgrouptherewasobviousdi
7、fference(P＜0．01)．Theaverageopticaldensityofmutantp53inWeiweikanglargedosegroupwasminimum，withsignificantdifferencecomparedtotheotherther-apeuticgroups(P＜0．01)．Conclusion:Weiweikangcanimproveandreversethegastricatrophyofexperimentalatrophicgastritisofrats，whichrelatedtodose．Itsmecha
8、nismmayberelatedwithrestra
