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1、遼寧中醫(yī)雜志2013年第40卷第10期·2155·萎胃康顆粒逆轉(zhuǎn)慢性萎縮性胃炎的p53機(jī)制研究12程艷,趙巖(1.濱州市人民醫(yī)院,山東濱州256603;2.濱州醫(yī)學(xué)院,山東煙臺(tái)264003)摘要:目的:探討萎胃康顆粒逆轉(zhuǎn)慢性萎縮性胃炎(CAG)的機(jī)制。方法:將90只SD大鼠隨機(jī)抽取18只為正常對(duì)照組(正常組),其余72只采用多重刺激6周復(fù)制大鼠CAG模型。確定造模成功的64只隨機(jī)分為4組,即模型對(duì)照組、萎胃康大劑量組、萎胃康小劑量組、三九胃泰組,分別ig生理鹽水、萎胃康高濃度水煎液、萎胃康低濃度水煎液和三九胃泰混懸液,1次/d。給藥30d后,觀察對(duì)大鼠胃黏膜
2、組織形態(tài)及突變型p53表達(dá)的影響。結(jié)果:模型組大鼠胃黏膜病理無明顯改善,突變型p53表達(dá)較正常組顯著升高(P<0.01);各治療藥物均可顯著改善胃黏膜萎縮,降低胃黏膜突變型p53表達(dá),較模型組具有顯著性差異(P<0.01)。其中以萎胃康大劑量組大鼠胃黏膜p53的平均光密度最低,較其他治療組有顯著性差異(P<0.01)。結(jié)論:萎胃康能改善和逆轉(zhuǎn)實(shí)驗(yàn)性萎縮性胃炎大鼠胃黏膜萎縮,其療效與劑量有關(guān),其機(jī)制可能與抑制細(xì)胞的異常增殖有關(guān)。關(guān)鍵詞:萎胃康;萎縮性胃炎;p53中圖分類號(hào):R573.32文獻(xiàn)標(biāo)志碼:B文章編號(hào):1000-1719(2013)10-2155-02
3、Researchonp53MechanismofWeiweikangReversingChronicAtrophicGastritis12CHENGYan,ZHAOYan(1.BinzhouPeople'sHospital,Binzhou256603,Shandong,China;2.BinzhouMedicalUniversity,Yantai264003,Shandong,China)Abstract:Objective:TodiscussthemechanismofWeiweikangreversingchronicatrophicgastritis.
4、Methods:18ratsfrom70SDratswererandomlyselectedoutasnormalcontrolgroup(normalgroup).Theremaining72ratsweremadeCAGmodelwiththemultiplestimulationsfor6weeks.Theremaining64ratswhichweremodeledsuccessfullywererandomlydividedintofourgroupssuchasmodelgroup,Weiweikanglargedosegroup,Weiweik
5、angsmalldosegroupandSanjiuWeitaigroup.Thegroupswereinjected0.9%saline,Weiweikanghighpotencydecoction,WeiweikanglowpotencydecoctionandSanjiuWeitaisuspension,onceaday.After30days,thegastricmucosapathologicalchangesandtheexpressionofmutantp53wereobserved.Results:Therewasnosignificantd
6、ifferentiationofgastricmucosapathematologyinmodelgroup.Theexpressionofmutantp53madeasignificantincreasecomparedwithmodelgroup(P<0.01).Thetherapeuticdrugsallcouldsignificantlyimprovegastricmucosaatrophyandreducetheexpressionofthemutantp53andcomparedwiththemodelgrouptherewasobviousdi
7、fference(P<0.01).Theaverageopticaldensityofmutantp53inWeiweikanglargedosegroupwasminimum,withsignificantdifferencecomparedtotheotherther-apeuticgroups(P<0.01).Conclusion:Weiweikangcanimproveandreversethegastricatrophyofexperimentalatrophicgastritisofrats,whichrelatedtodose.Itsmecha
8、nismmayberelatedwithrestra