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1、南方醫(yī)科大學(xué)(第一軍醫(yī)大學(xué))珠江醫(yī)院麻醉科徐世元肌松藥的規(guī)范應(yīng)用與拮抗及監(jiān)測Evaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.人們都這么說!現(xiàn)在的麻醉好上多了!Evaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.在運(yùn)動神經(jīng)終板制造的矛盾神經(jīng)-肌肉“傳導(dǎo)--
2、阻滯--傳導(dǎo)”Evaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.殘余肌松作用是麻醉恢復(fù)期的殺手!Tiret(法國)20萬例全麻病人中,麻醉死亡65例。半數(shù)的麻醉死亡是因殘余肌松呼吸抑制。Lunn(英國)11例全麻后呼吸抑制6例與殘余肌松作用有關(guān)。Australia近20年麻醉死亡的主要原因之-是殘余肌松作用拮抗不全Evaluationonly.CreatedwithAspose.Slidesfor.NE
3、T3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.Canada5%-10%Denmark5%-10%France33%-42%VecuroniumAtracuriumNoreversal,NomonitorEvaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.肌松藥殘余作用最近Nagui等分析1979年至2005年共24組資料、3375例病人。術(shù)
4、中應(yīng)用肌松監(jiān)測823例,24.4%;應(yīng)用神經(jīng)刺激器543例。其它分析結(jié)果如下參考文獻(xiàn):NaguibM,KopmanAF,EnsorJE.NeuromuscularmonitoringAndpostperativeresidualcurarization:ameta-analysis.BrJAnaesthesia,2007,98(3):302-316.Evaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.在肌
5、松監(jiān)測下新斯的明拮抗后殘余肌松作用長效肌松藥TOF比值<0.74%—60%<0.953%—93%中效肌松藥TOF比值<0.70%—45%<0.912%—95%Evaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.肌松監(jiān)測未減少肌松殘余作用發(fā)生率(對傳統(tǒng)觀念的否定)臨床估評法較肌松監(jiān)測法肌松殘余作用發(fā)生率高神經(jīng)刺激器法肌松殘余作用發(fā)生率較上述兩種方法發(fā)生率低結(jié)論Evaluationonly.Createdwi
6、thAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.臨床麻醉肌松藥規(guī)范應(yīng)用的重要性!Evaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.一、肌松藥的臨床應(yīng)用劑量Evaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Cop
7、yright2004-2011AsposePtyLtd.問題一:在全麻誘導(dǎo)或維持時不論病人體重與其ED95,只大約應(yīng)用多少劑量。此種用法在無肌松監(jiān)測條件下,難以估測大致肌松程度,因而不能依據(jù)手術(shù)需要合理調(diào)控肌松藥用量●與其他全麻藥甚至局麻藥、鎮(zhèn)痛藥比較,僅肌松藥可按體重與ED95調(diào)控所需肌松程度,即使無肌松監(jiān)測條件,個體差異大,亦能作出大體判斷Evaluationonly.CreatedwithAspose.Slidesfor.NET3.5ClientProfile5.2.0.0.Copyright2004-2011AsposePtyLtd.●無論全麻
8、誘導(dǎo)或維持,均應(yīng)按體重—ED95計算肌松藥用量※全麻誘導(dǎo)、氣管插管、肌松藥用量為2~3個ED9