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1、心臟死亡兒童供體單腎移植的療效分析1.中南大學(xué)湘雅三醫(yī)院湖南長(zhǎng)沙410013目的:評(píng)估供體年齡在2歲以上的心臟死亡兒童供體單腎移植(SPKT)的臨床療效,并探討其應(yīng)用價(jià)值。方法:回顧性分析我中心自2010年到2014年開(kāi)展的26例SPKT和109例心臟死亡標(biāo)準(zhǔn)供體腎移植(SCDKT)。對(duì)比兩種腎移植術(shù)后供受體的基木資料及術(shù)后早期并發(fā)癥的發(fā)生率,比較、分析兩種腎移植術(shù)后1年內(nèi)移植腎的長(zhǎng)徑、功能、移植腎存活率和受者存活率之間的差異,評(píng)估心臟死亡兒童供體單腎移植的臨床療效。結(jié)果:SPKT組與SCDKT組術(shù)后早期并發(fā)癥的發(fā)生
2、率無(wú)明顯差異(P>0.05);SPKT術(shù)后移植腎的成長(zhǎng)能力明顯優(yōu)于SCDKT組;兩組術(shù)后各時(shí)間點(diǎn)的腎小球?yàn)V過(guò)率(eGFR)、移植腎存活率及人存活率之間均無(wú)統(tǒng)計(jì)學(xué)差異(P>;0.05)o結(jié)論:當(dāng)心臟死亡兒童供體的年齡大于2歲時(shí),SPKT不僅術(shù)后移植腎有良好的成長(zhǎng)能力,其臨床療效也可與SCDKT相媲美,是尿毒癥患者的理想選擇,其合理應(yīng)用有助于擴(kuò)大器官來(lái)源?!娟P(guān)鍵詞】心臟死亡捐獻(xiàn);兒童供體;腎移植;體表面積Theanalysisofoutcomesonsinglepediatrickidneytransplant
3、ationfromcardiacdeathdeceaseddonorsZhi-tanPENG1,Qi-faYE1,KeCHENGl,Yu-junZHAOl,LianUU1,QiangWANG1(l.TheThirdXiangyaHospitalofCentralSouthUniversity,Changsha,Hunan410013;)AbstractObjective:Toanalyzetheoutcomesanddiscusstheapplicationofsinglepediatrickidneytranspl
4、antation(SPKT)fromcardiacdeathdeceaseddonors(2-18yr).Methods:Weretrospectivelyanalyzed26casesofSPKTfromcardiacdeathdeceaseddonorsand109casesofstandard-criteriadonorkidneytransplantation(SCDKT)thatwereperformedinourcenterfrom2010through2O14.Weanalyzedtheoutcomes
5、ofSPKTbyconductingcomparisonbetweenSPKTandSCDKTindemographicsofpatients,earlypostoperativecomplications,thelengthandfunctionofgrafts,andgraftandpatientsurvival.Results:TherewasnodifferencebetweenSPKTandSCDKTinpostoperativecomplications(P>0.05).Thelengthofgra
6、ftwithinhalfayearinSPKTwasmuchshorterthanthatofSCDKT(P<0.05),however,thelengthofeachgroupbecamealmostequivalentastimewenton.NosignificantdifferencewasshownbetweeneachgroupineGFR,graftandpatientsurvivalpostkidneytransplantation.Conclusion:Oncetheageofpediatri
7、cdonorsisabove2yrs,theSPKTcanobtaincomparableoutcomestoSCDKTandbettercapacityofgraftgrowth,whichisanidealchoiceforuremiapatients.Appropriateuseofpediatricdonorscansignificantlyexpandthedonorpool.Keywords:donationaftercardiacdeath;pediatricdonor;kidneytransplant
8、ation;bodysurfacearea對(duì)終末期腎病患者而言,腎移植無(wú)疑是最好的選擇[1】。然而,隨著每年新發(fā)尿毒癥病人數(shù)量的逐年累加,供腎的來(lái)源卻相對(duì)奮限,器官短缺問(wèn)題越來(lái)越嚴(yán)重。國(guó)內(nèi)外各研究中心努力嘗試從多方面擴(kuò)人器官來(lái)源以緩解腎移植等待名單日益增多與器官嚴(yán)重短缺之間的矛盾。比如心臟死亡老年供體(>65歲),心臟死亡兒童供體(<