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1、載藥微球經(jīng)導(dǎo)管動脈化療栓塞治療肝癌研究進(jìn)展趙倩顏志平復(fù)旦大學(xué)附屬中山醫(yī)院介入科、上海市影像醫(yī)學(xué)研宄肝細(xì)胞肝癌是肝臟最常見原發(fā)性惡性腫瘤，經(jīng)導(dǎo)管動脈化療栓塞術(shù)（TACE）是外科手術(shù)不能切除中晚期肝癌首選的有效治療方法。載藥微球TACE術(shù)是一種新興治療方式，能夠持續(xù)緩慢釋放化療藥物，提高藥物局部濃度，降低全身血藥濃度。在超選擇基礎(chǔ)上，直徑＞100um載藥微球TACE術(shù)安全有效，在腫瘤緩解率、減少手術(shù)次數(shù)、減少不良反應(yīng)、縮短住院時(shí)間、提高生活質(zhì)量等方而均較傳統(tǒng)TACE術(shù)具有優(yōu)勢，對中期、Child-PughB級、體能活動狀況1級、有兩葉病變、復(fù)發(fā)性疾病患者治療效果較好。但價(jià)
2、格昂貴及當(dāng)?shù)蒯t(yī)療條件、醫(yī)務(wù)人員能力、醫(yī)保政策等限制了載藥微球臨床應(yīng)用。載藥微球TACE治療肝癌臨床效果，有待進(jìn)一步研宄證實(shí)。關(guān)鍵詞：肝細(xì)胞肝癌;經(jīng)導(dǎo)管動脈化療栓塞術(shù);載藥微球;顏志平E-mail:yan.zhiping@zs-hospital.sh.cn2016-10-08Transarterialchemoembolizationwithdrug-elutingbeadsforthetreatmentofhepatocellularcarcinoma:recentprogressinresearchZHAOQianYANZhipingDepartmentofInte
3、rventionalRadiology,AffiliatedZhongshanHospital，F(xiàn)udanUniversity，ShanghaiInstituteofMedicalImaging;Abstract：Hepatocellularcarcinoma(HCC)isthemostcommonprimarymalignantlivercancer.Transarterialchemoembolization(TACR)hasbeenthepreferredeffectivetreatmentforunrcscctablcadvancedIICCTACEwithd
4、rug-elutingbeadsisanewlyemergingtherapeuticmeans,withwhichthechemotherapydrugscanbecontinuouslyandslowlyreleasedintothetumortissue,thus,increasingthelocaldrugconcentrationandreducingserumdrugconcentration.Theuseofdrug-elutingbeadswith>100umdiameterissafeandeffectivewhensuper-selectiveca
5、theterizationofthetumor-feedingarteryissuccessfullyaccomplished.TACEwithdrug-elutingbeadsissuperiortotraditionalTACEinimprovingtumorremissionrate,decreasingthenumberofoperations,reducingadversereactions,shorteninghospitalizationtime,improvingthequalityoflife,etc.Thistherapyismoreeffecti
6、veforthepatientswhohaveadvancedlivercancer，Child-PughBgradeliverfunction,levelIphysicalactivitystatus,lesionsoftwohepaticlobes,andrecurrentHCC.Becauseofexpensivemedicalcost,needofhigh-qualitymedicalconditionsandexperiencedmedicalstaffers,aswellasneedoffullyguaranteedhealthinsurancepolic
7、y,theclinicalapplicationofdrugelutingbeadshasbeenlimited.TheclinicaleffectofTACEwithdrug-elutingbeadsneedstobefurtherstudiedandproved.Keyword：hepatocellularcarcinoma;transcatheterarterialchemoembolization;drug-elutingbead;Received：2016-10-08肝細(xì)胞肝癌是肝臟最常見原發(fā)性惡性腫瘤，發(fā)病率、致死率在世界范圍內(nèi)分別占第6
