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1、康萊特聯(lián)合同步放化療治療中晚期宮頸癌的臨床觀1.貴州醫(yī)科大學附屬貴州省人民醫(yī)院貴州貴陽550002；2.貴州省人民醫(yī)院貴州貴陽550002【摘要】目的：探討康萊特注射液聯(lián)合同步放化療治療中晚期宮頸癌的近期療效、毒副反應及耐受性。方法：107例lib?IVa期宮頸癌初治患者采用隨機法分為實驗組和對照組，實驗組：康萊特注射液200ml靜滴dl-d2l4?圖像引導調(diào)強放療(IGRT)盆腔放療+單藥順鉑30mg/m2每周一次。對照組：IGRT盆腔放療+單藥順鉑30mg/m2每周一次。兩組盆腔外照射劑量及后裝劑量相同。
2、結(jié)果：兩組近期有效率：實驗組為89%,對照組為73%,兩組比較差異有統(tǒng)計學意義(P<0.05);白細胞減少、血紅蛋白減少及腹痛腹瀉的發(fā)生率實驗組低于對照組，差異有統(tǒng)計學意義(P<0.05),但在肝功能損害方面，實驗組高于對照組差異有統(tǒng)計學意義(P<0.05),其余毒副反應評價差異無統(tǒng)計學意義(P〉0.05)。結(jié)論：康萊特注射液聯(lián)合同步放化療治療中晚期宮頸癌的近期療效肯定、毒副反應較輕(肝功能損害除外)、病人耐受性好。【關鍵詞】康萊特注射液；宮頸癌；同步放化療；圖像引導調(diào)強放療；順鉑[Abstract]Obje
3、ctive：ToinvestigateKanglaiteinjectioncombinedwithradiotherapyandthecurativeeffectofchemotherapyinthetreatmentofadvancedcervicalcancer,toxicityandpatienttolerance.Methods:107casesatthebeginningofthelib?IVacervicalcarcinomaofstagetreatmentpatientswererandomly
4、dividedintotheexperimentalgroupandthecontrolgroup，theexperimentalgroup55cases,controlgroup(52cases).Theexperimentalgroupadopted：Kanglaiteinjection200mlintravenousdripdl-d21+imageguidedintensity-modulatedradiotherapy(IGRT)pelvicradiotherapy+singleagentcispla
5、tin30mg/m2perweekatatime.ThecontrolgroupwasusedforIGRTpelvicradiotherapypluscisplatin30mg/m2onceaweek.ThetwogroupswerethesameastheexternalradiationdoseandtheInternalirradiationdoseofthesame.Results：Twogroupsofrecentefficiency：intheexperimentalgroupwas89%and
6、73%inthecontrolgroup，thedifferencebetweenthetwogroupshasstatisticalsignificance(P<0.05)；leucopeniadecreaseinhemoglobinandabdominalpainanddiarrheaincidencerateoftheexperimentalgroupwaslowerthanthatofthecontrolgroup,thedifferenceisstatisticallysignificant/
7、P<0.05),butinliverfunctiondamage，theexperimentalgrouphigherthanthatofthecontrolgroup，thedifferencewasstatisticallysignificant(P<0.05),thetoxicandsideeffectstoevaluatedifferencesnostatisticalsignificance(P>0.05).Conclusions：Kanglaiteinjectioncombine
8、dwithradiotherapyandchemotherapyinthetreatmentofadvancedcervicalcancerrecentcurativeeffectandadversereactionoflighter(exceptforliverfunctiondamage)，patienttoleranceisgood.Keywords：KanglaiteInjectionChe
