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《同型半胱氨酸、N端腦鈉肽前體及超敏C反應(yīng)蛋白在缺血性腦卒中患者中的臨床價值.pdf》由會員上傳分享,免費在線閱讀,更多相關(guān)內(nèi)容在應(yīng)用文檔-天天文庫。
1、956JBengbuMedColl,Julv2014,Vo1.39.No.7[文章編號]1000-2200(2014)07-0956-04·檢驗醫(yī)學·同型半胱氨酸、N端腦鈉肽前體及超敏C反應(yīng)蛋白在缺血性腦卒中患者中的臨床價值王敏,汪春華,劉群,徐轉(zhuǎn)[摘要]目的:探討同型半胱氨酸(homocysteine,Hcy)、N端腦鈉肽前體(N.terminalprohormoneofbrainnatriuretic,NT-proBNP)及超敏C反應(yīng)蛋白(highsensitivityCreactiveprotein,hs—CRP)與缺血性腦卒中(isch
2、emicstroke,IS)初發(fā)和復(fù)發(fā)的相關(guān)性,為臨床診斷、病情評估和預(yù)后判斷提供科學依據(jù)。方法:以216例Is患者為研究對象,其中初發(fā)134例,復(fù)發(fā)82例,并選取100名健康體檢者為對照組,分別檢測3組受試者的Hcy、NT—proBNP、hs.CRP的變化水平,同時對Is初發(fā)和復(fù)發(fā)的因素進行多元logistic回歸分析。結(jié)果:初發(fā)和復(fù)發(fā)Is患者的Hcy、NT—proBNP和hs—CRP水平均顯著高于對照組(P<0.01),且復(fù)發(fā)組的Hcy、NT—proBNP和hs—CRP水平均明顯高于初發(fā)Is組(P<0.01);復(fù)發(fā)Is組Hcy、NT—pro
3、BNP、hs.CRP高于正常范圍值患者分別占56.10%、38.06%和74.39%,均顯著高于初發(fā)Is組的38.06%、26.87%和36.57%(P<0.01);多元logistic回歸分析Hcy、NT-proBNP和hs—CRP水平的升高均是Is初發(fā)的獨立危險因素,而罹患糖尿病和機體Hcy、NT.proBNP和Hs—CRP水平的升高均是Is復(fù)發(fā)的獨立危險因素。結(jié)論:Is患者的Hcy、NT—proBNP、hs—CRP水平顯著高于健康人群,且復(fù)發(fā)Is的檢測指標水平亦高于初發(fā)患者,高水平的Hcy、NT—proBNP、hs—CRP均是Is初、復(fù)發(fā)
4、的獨立高危因素。[關(guān)鍵詞]缺血性腦卒中;同型半胱氨酸;腦鈉肽;超敏C反應(yīng)蛋白[中國圖書資料分類法分類號]R743.3[文獻標志碼]ATheclinicalvalueonplasmahomocysteine,N·terminalprohormoneofbrainnatriureticandhighsensitivityCreactiveproteininpatientswithischemicstrokeWANGMin,WANGChun—hua,LIUQun,xuZhuan(DepartmentofClinicalLaboratory,TheSe
5、condAffiliatedHospitalofBengbuMedicalCollege,BengbuAnhui233040,China)[Abstract]Objective:Toinvestigatetherelationshipsamongthelevelsofplasmahomocysteine(Hcy),N·terminalprohormoneofbrainnatriuretic(NT—proBNP),highsensitivityCreactiveprotein(hs—CRP)andischemicstroke(IS)onsetan
6、drecurrence,andprovidethescientificbasisforclinicaldiagnosis,conditionassessmentandprognosis.Methods:Total216patientswithISfromDec.2011toAug.2013wererecruited,134caseswithISinitialonset,and82caseswithrecurence,meanwhile100healthypersonswereselectedascontrolgroup.PlasmaHcy,NT
7、—proBNPandhs·CRPlevelsinthethreegroupsweremeasured.ThefactorsinISinitialonsetandrecurencewerecarriedoutinmultiplelogisticregressionanalysis.Results:TheplasmaHcy,NT—proBNPandhs—CRPlevelsinprimaryandrecurrentISpatientsweresignificantlyhigherthanthatincontrolgroup(P<0.O1);Hcy,N
8、T—proBNPandhs·CRPlevelsintherecurrencegroupweresignificantlyhigherthanthati