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《nk細胞功能與hcv感染及抗病毒治療轉歸的研究》由會員上傳分享，免費在線閱讀，更多相關內(nèi)容在學術論文-天天文庫。
1、華中科技大學碩士學位論文NKcells,buttherewasnostatisticdifference.(4).WefoundthosewhoachievedspontaneousviralclearancehadasignificanthigherlevelofNKcells,NKp46,NKG2Cexpression,accompaniedwithvigonusTNF-αsecretioncomparedtopatientsnotinSVR(p＜0.05).2.Aftercultivation
2、,PBMCsfromuntreatedHCVinfectedpatientsshowedlessfrequenciesofNKcellthancontrols(p＜0.01),onthecontrary,higherproportionofNKG2AandNKG2Cthancontrols(p＜0.05).PatientsnotinSVRdisplayedadiminishedabilitytosecretecytokinescomparedtohealthycontrols(p＜0.05).3.V
3、iraltiterandALTshowednocorrelationwithfunctionalmarkersofNKcellsinuntreatedpatientsandthosewhowerenotinSVR.4.Changesofphenotypes,receptorsandfunctionsofNKcellsinpatientsbeingonantiviraltreatment.(1).PatientswithGenotype2or3andinlowervirallevelsshowedex
4、pandedCD56brightsubsetandreducedCD56dimsubsetduringtherapy,howeverpatientswithGenotype1andhigherviraltiternot.(2).ExpansionofproportionofNKG2AwithdiminishedfrequencesofactivereceptorswasfoundinpatientswithGenotype1andhigherviralloadduringtreatment.(3).
5、NKcellspresentedreducedcytotoxicityandabilitytoproducecytokine,especiallyinpatientswithGenotype1andinhighervirallevels.Conclusion1.FunctionsofNKcellswereassociatedwithHCVinfectionandoutcome.ImpairedactivitiesofNKcellswereobservedinpatientswithchronicHC
6、Vinfection.ButthosewhoeliminatedHCVspontaneouslyorinSVRdisplayedmoreactivefunctionsofNKcellsthanchronicallyinfectedpatients.2.ActivitiesofNKcellsbothinvivoandinvitroweredifferentbetweenpatientswithHCVinfectionandhealthycontrols.3.ViraltiterandALTshowed
7、nocorrelationwithfunctionalmarkersofNKcellsin7華中科技大學碩士學位論文untreatedpatientsandthosewhowerenotinSVR.2.FunctionsofNKcellswerenotrestored,evenseverelyreducedbytreatmentinpatientswithGenotype1andhigherviralloadcomparedtopatientswithGenotype2or3andlowerviru
8、stiterwhoshowedslightlychanges.Keywords:HepatitisCvirus,Naturalkillercells,Antiviraltherapy,PrognosisThisworkswassupportedbygrantsfromtheNationalKeyBasicResearchProgramofChina(2009CB522500)andtheNationalMegaResearchProgramofChina(2008ZX
