資源描述：
《依貝沙坦與卡托普利聯(lián)合治療充血性心力衰竭的療效論文》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、依貝沙坦與卡托普利聯(lián)合治療充血性心力衰竭的療效論文周泉，胡振玉，吳大方，張同利，鐘筱蘭【關(guān)鍵詞】充血性心力衰竭Captoprilbinedentofdigitalis,diureticsandβblockingagent,lydividedintogroupAandgroupB.GroupA(n=60)g/dandirbesartan75-300mg/dandGroupB(n=60)g/d.ThechangesofNYHAclass,biochemistry,liverfunction,renalfunction,electrocardiogramandechocardiograph
2、yent,leftatrium（LA）diameter,leftventricularenddiastolicdiameter（LVDD）,leftventricularendsystolicdiameter（LVSD）andleftventricularejectionfraction(EF)provedsignificantlyinbothgroups(P0.01).LVDD,LVSDEFandNYHAclassoresignificantingroupAthanthoseingroupB(P0.05).Thereentbetoreeffectivethancaptoprilal
3、oneinthetreatmentofpatientsg/d，卡托普利75~150mg/d；B組(n=60)口服卡托普利50~150mg/d.治療前后進行心功能NYHA分級評估，行血生化、肝腎功能、心電圖、超聲心動圖檢查.結(jié)果：治療12mHg(1mmHg=0.133kPa)及有明顯肝腎功能損害者.分為A,.freelg/d，聯(lián)合口服依貝沙坦（杭州賽諾菲圣德拉堡民生制藥有限公司）75~300mg/d.B組口服卡托普利50~150mg,qd.兩組藥物使用的劑量根據(jù)血壓和患者耐受情況調(diào)整，在患者不出現(xiàn)頭昏、頭暈、惡心癥狀，血壓穩(wěn)定、耐受良好時盡量增加卡托普利及伊貝沙坦的劑量.治療前和治療后
4、12izedtrialofLosartanversuscaptoprilinpatientsover65entonthediagnosisandtreatmentofcongestiveheartfailure［J］.ChinJCardiol,2003;31:641-645.［3］DallaLiberaL,RavaraB,AngeliniA，etal.BeneficialeffectsonskeletalmuscleoftheangiotensinIItype1receptorblockerirbesartaninexperimentalheartfailure［J］.Circula
5、tion,2001;103:2195-2200.［4］UrataH,KinoshitaA,MisonoKS,etal.IdentificationofahighlyspecificchymaseasthemajorangiotensinⅡformingenzymeinthehumanheart［J］.JBiolChem,1990;265(36):22348-22357.［5］BrunnerLaRoccaHP，VaddadiG，EslerMD.Recentinsightintotherapyofcongestiveheartfailure：FocusonACEinhibitionand
6、angiotensinⅡantagonism［J］.JAmCollCardiol，1999；33（5）：1163-1173.［6］吳向明.纈沙坦治療充血性心力衰竭臨床觀察［J］.臨床心血管病雜志,2001;17(12):557-559..TheclinicalefficacyofValsartanonthetreatmentofcongestiveheartfailure［J］.JClinCardiol,2001;17(12):557-559.［7］CohnJN,TognoniG.Arandomizedtrialoftheangiotensinreceptorblockerirbes
7、artaninchronicheartfailure［J］.NEnglJMed,2001;345:1667-1675.［8］嚴(yán)紅，林曙光，陳魯原，等.氯沙坦與依那普利聯(lián)用對慢性心力衰竭患者左室功能的影響［J］.中華心血管病雜志，2000；28：230.YanH,LinSG,ChenLY,etal.StudyoftheeffectsofEnalaprilbinedLosartanonleftventricularfunctioninpatientsentof
