相控陣熱療聯(lián)合吉西他濱治療胰腺癌的臨床觀察

《相控陣熱療聯(lián)合吉西他濱治療胰腺癌的臨床觀察》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。

1、相控陣熱療聯(lián)合吉西他濱治療胰腺癌的臨床觀察川北醫(yī)學(xué)院第二臨床學(xué)院腫瘤中心四川南充637000【摘要】目的：觀察相控陣熱療聯(lián)合吉西他濱治療胰腺癌的療效及毒性反應(yīng)。方法：34例伴有疼痛的局部晚期和復(fù)發(fā)的胰腺癌患者隨機(jī)分為熱療聯(lián)合吉西他濱化療組(研究組)17例和單純吉西他濱化療組(對(duì)照組)17例，研究組接受相控陣熱療，每周2次，計(jì)劃8次，聯(lián)合吉西他濱1000mg/m2,dl、8、15,每28天重復(fù)一次，對(duì)照組接受吉西他濱1000mg/m2,dl、8、15,每28天重復(fù)一次，觀察阿片類藥物劑量增減情況、毒副反應(yīng)及近期療效。結(jié)果：治療開始2個(gè)月內(nèi)，研究組阿片類藥物用量減少大于對(duì)

2、照組(P<0.01),2組患者IIIJV度白細(xì)胞降低、血小板降低發(fā)生率無差異(P>0.05),近期有效率在研究組和對(duì)照組分別為20.2%(3/15)和13.3%(2/15),(P>0.05)。結(jié)論：相控陣熱療聯(lián)合吉西他濱治療局部晚期和復(fù)發(fā)胰腺癌，與單用吉西他濱相比，能明顯減少阿片類藥物用量，毒性反應(yīng)輕，近期療效無差異。【關(guān)鍵詞】胰腺癌；相控陣熱療；吉西他濱【中圖分類號(hào)】R735.9【文獻(xiàn)標(biāo)識(shí)碼】B【文章編號(hào)】1764-8999(2015)7-0749-02Clinicalobservationofarraysystenforhyperthermiacombinedwi

3、thgemcitabineforpancreaticcarcinomaHUXin,LIGuang-ming,WENShi-min,LIShuang,CHENSi-lin,PANRong-qiang,BIEJun,ZHAOCai-xia,FUXi,CHENQiao-ling,SONGJun-mei,HUXing-sheng,(DepartmentofOncology,SecondClinicalInstituteofNorthSichuanMedicalCollege,NanchongSichuan637000China)【Abstract】Objective:Toob

4、servetheefficacyandtoxicityofarraysystemforhyperthermiagemcitabineforpancreaticcarcinoma.Methods:34casespatientswithlocaladvancedandrecurrentpancreaticcarcinomawererandomlybydividedintostudygroup17casestreatedwitharraysystemforhyperthermia2timesaweekcombinedwithgemcitabine(1000mg/m2dl,8

5、,15,per28dayacycle)andcontrolgrouptreatedwithalonegemcitabine(1000mg/m2￡11,8,15,per28dayacycle),theincreaseanddecreaseofopioidconsumptionwererecordedandtoxicityandshort-timeeffectwereobserved.Results:Inthenext2monthsafterbeginningtherapy,theopioidconsumptionofstudygroupwasdecreasedmoret

6、hanthatofcontrol(P<0.01),therewerenotsignificantdifferencebetween2groupinIII-IV°leukocytopenia(P>0.05)andIII-IV°thrombocytopenia(P>0.05),theshort-timeresponseratewas20.0%(3/15)instudygroupand13.3%(2/15)incontrolgroup(P>0.05).Conclusion:Comparedwithalonegemcitabine,arraysystemfor

7、hyperthermiacombinedwithgemcitabineforlocaladvaneedandrecurrentpancreaticcarcinomacansign訐icantlydecreaseopioidconsumption.【KEYWORDS]Arraysystemforhyperthermia;Gemcitabine;Pancreaticcarcinoma.胰腺癌是惡性程度極高的消化道腫瘤，目前手術(shù)作為唯一根治手段，由于超過80%患者確診吋已屬晚期，可行根治性切除手術(shù)者不足20%,術(shù)后5年生存率低于4%,局部復(fù)發(fā)是主要的治療失