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1、分類號(hào)R392密級(jí)：單位代碼：10422，學(xué)號(hào)：201113334碩士學(xué)位論文ThesisforMasterDegree論文題目：CUL4BE3泛素連接酶調(diào)控HBV復(fù)制的分子機(jī)制研究TheregulationofCUL4BonHBVreplicationanditsmolecularmechanisms作者姓名培養(yǎng)單位專業(yè)名稱單海霞醫(yī)學(xué)院免疫學(xué)指導(dǎo)教師梁曉紅副教授合作導(dǎo)師2014年5月14日原創(chuàng)性聲明本人鄭重聲明：所呈交的學(xué)位論文，是本人在導(dǎo)師的指導(dǎo)下，獨(dú)立進(jìn)行研究所取得的成果。除文中已經(jīng)注明引用的內(nèi)容外，本論文不包含任何其他個(gè)人或集體已經(jīng)發(fā)表或撰寫過的科研成果。對(duì)本文的研究作出重要貢獻(xiàn)的
2、個(gè)人和集體，均己在文中以明確方式標(biāo)明。本聲明的法律責(zé)任由本人承擔(dān)。論文作者簽名：夔逝盈日期：幻／節(jié)．，-2’關(guān)于學(xué)位論文使用授權(quán)的聲明本人同意學(xué)校保留或向國家有關(guān)部門或機(jī)構(gòu)送交論文的印刷件和電子版，允許論文被查閱和借閱；本人授權(quán)山東大學(xué)可以將本學(xué)位論文的全部或部分內(nèi)容編入有關(guān)數(shù)據(jù)庫進(jìn)行檢索，可以采用影印、縮印或其他復(fù)制手段保存論文和匯編本學(xué)位論文。(保密論文在解密后應(yīng)遵守此規(guī)定)論文作者簽名：塑亟導(dǎo)師簽名：．監(jiān)生日期：蘭!蘭莖：!≥目錄中文摘要????????????????????????????一1英文摘要????????????????????????????一8符號(hào)說明??????
3、????????????????????????????????17第一部分CUL4BE3泛素連接酶對(duì)HBV復(fù)制的調(diào)控作用第一章前言(含文獻(xiàn)綜述)???????????????????·19第二章材料????????????????????????????24第三章方法???????????????????????????????·29第四章結(jié)果???????????????????????????????·38第五章討論???????????????????????????43第二部分HBx在CUL4B調(diào)控HBV復(fù)制中的作用第一章前言(含文獻(xiàn)綜述)????????????????????
4、?45第二章材料?????????????????????????一47第三章方法?????????????????????????一49第四章結(jié)果??????????????????????????????????54第五章討論?????????????????????????????????··62參考文獻(xiàn)????????????????????????????64致謝???????????????????????????????????·71相關(guān)論文發(fā)表和成果???????????????????????··72CATALOGUEAbstractinChinese??????????
5、????????????????????????1AbstractinEnglish·····································································································。8SymbolicDescription。································································································17PartIRegulationofCUL4BE3ubiquitinli
6、gaseonHBVreplicationChapterlIntroduction?！ぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁぁ?·······················································。19Chapter2Materials‘?··?·??····?·?·?··?·?··??··?·?···?·?·???··?·?????·?24Chapter3Methods’·······································································
7、···············29Chapter4Results’·?·?··?··??·???··?·?··?··??··??··?·?·??·?··?·?··??···38Chapter5Discussion‘·····················································································43PartIITheroleofHBx
