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《護(hù)腸清毒微丸治療慢性乙型病毒性肝病繼發(fā)腸源性內(nèi)毒素血癥的臨床研究》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、提要目的：通過觀察分析護(hù)腸清毒微丸治療慢性乙型病毒性肝病患者繼發(fā)腸源性內(nèi)毒素血癥的臨床療效，為臨床治療本病提供安全有效、經(jīng)濟(jì)便捷、依從性高的治療方法。方法：將215例慢性乙型病毒性肝病繼發(fā)腸源性內(nèi)毒素血癥患者隨機(jī)分為四組：口服中藥組、口服護(hù)腸清毒微丸組、護(hù)腸清毒湯灌腸組、口服乳果糖組。中藥組予常規(guī)綜合治療加用口服治療慢乙肝的中藥復(fù)方；護(hù)腸清毒微丸組為中藥組加口服護(hù)腸清毒微丸；護(hù)腸清毒湯組為中藥組+護(hù)腸清毒湯保留灌腸；乳果糖組為中藥組加口服乳果糖。四組療程均為20天。觀察治療前后血漿內(nèi)毒素、TNF-α、IL-6、IL-8、肝功以及中醫(yī)證候
2、積分的變化。結(jié)果：護(hù)腸清毒微丸能顯著降低慢性乙型病毒性肝病伴腸源性內(nèi)毒素血癥患者內(nèi)毒素、細(xì)胞炎性因子，改善肝功能和顯著改善臨床癥狀。結(jié)論：護(hù)腸清毒微丸治療慢乙肝繼發(fā)腸源性內(nèi)毒素血癥療效確顯著?！皾駸岫攫鎏N(yùn)結(jié)大腸”是其基本病機(jī)，“健脾調(diào)腸、化瘀解毒”為其治法。關(guān)鍵詞慢性乙型病毒性肝病；腸源性內(nèi)毒素血癥；護(hù)腸清毒微丸；口服結(jié)腸靶向給藥系統(tǒng)。TheClinicalResearchofTreatmentofChronicViralHepatitisTypeBAccompyingIntestinalEndotoxiemiabyHuChangQin
3、gDuPelletsSpeciality:InternalMedicineofTCMAuthor:HouChenyangTutor:Prof.LiYongAbstractObjective:HuChangQingDupellets’sefficacyofthetreatmentofChronicViralHepatitisTypeBAccompyingIntestinalEndotoxiemia,toprovidesafeandeffectivefortheclinicaltreatmentofthisdisease,economica
4、landconvenient,hightreatmentcompliancebyobservingandanalyzing.Methods:The215patientsweredividedintofourgroupsbymeansofrandomnumbertable.ChinesemedicinetreatmentgroupweretreatedbytraditionalChinesemedicinegivenorallyonthebasisofroutinecomprehensivetherapy.HuChangQingDuWei
5、PillgroupweretreatedwithHuChangQingDupelletsgivenorallyonthebasisofChinesemedicinetreatmentgroup.HuChangQingDudecoctiontreatmentgroupweretreatedwithHuChangQingDudecoctionforretentionenemaonthebasisofChinesemedicinetreatmentgroup.Lactulosetreatmentgroupweretreatedwithlact
6、ulosetakenorallyonthebasisofChinesemedicinetreatmentgroup.Thecourseoftreatmentofallthefourgroupswas20days.Observeandnotethechangeofendotoxin,TNF-α、IL-6、IL-8,pointsofTCMsyndromemanifestationsinpatientsbeforeandaftertreatmentandstatisticalanalysiswasconducted.Results:HuCha
7、ngQingDupelletscansignificantlyreduceendotoxemiainpatientswithchronichepatitisBvirusliverdiseasewithgut-derivedtoxins,inflammatoryfactors,improvingliverfunctionandsignificantimprovementinclinicalsymptoms.Conclusion:HuChangQingDupelletstreatmentofChronicViralHepatitisType
8、BAccompyingIntestinalEndotoxiemiaefficacyisindeedsignificant.”HotandhumidtoxicstasisAccumulationcolon”i
