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1、授予單位代碼10089學(xué)號或申請?zhí)?3519HebeiMedicalUniversity碩士學(xué)位論文在職科學(xué)學(xué)位200例胃底腺息肉臨床病理特征分析學(xué)位申請人：阮聯(lián)英導(dǎo)師：張杰英教授專業(yè)：病理學(xué)與病理生理學(xué)二級學(xué)院：基礎(chǔ)醫(yī)學(xué)院2015年3月河北醫(yī)科大學(xué)學(xué)位論文使用授權(quán)及知識產(chǎn)權(quán)歸屬承諾本學(xué)位論文在導(dǎo)師(或指導(dǎo)小組)的指導(dǎo)下，由本人獨立完成。本學(xué)位論文研究所獲得的研究成果，其知識產(chǎn)權(quán)歸河北醫(yī)科大學(xué)所有。河北醫(yī)科大學(xué)有權(quán)對本學(xué)位論文進行交流、公開和使用。凡發(fā)表與學(xué)位論文主要內(nèi)容相關(guān)的論文，第一署名為單位河北醫(yī)科
2、大學(xué)，試驗材料、原始數(shù)據(jù)、申報的專利等知識產(chǎn)權(quán)均歸河北醫(yī)科大學(xué)所有。否則，承擔(dān)相應(yīng)法律責(zé)任。研究生簽名：導(dǎo)師簽章。^級學(xué)院領(lǐng)導(dǎo)蓋章：：乂年T月巧曰河北醫(yī)科大學(xué)研究生學(xué)位論文獨創(chuàng)性聲明本論文是在導(dǎo)師指導(dǎo)下進行的研究工作及取得的研究成果,除了文中特別加以標(biāo)注和致謝等內(nèi)容外,文中不包含其他人已經(jīng)發(fā)表或撰寫的研究成果,指導(dǎo)教師對此進行了審定。本論文由本人獨立撰寫，文責(zé)自負(fù)。研究生簽名：目錄中文摘要···························································
3、··················1英文摘要·············································································4研究論文200例胃底腺息肉臨床病理特征分析前言·············································································8材料與方法················································
4、····················8結(jié)果·············································································11附圖·············································································13附表······································································
5、·······18討論·············································································20結(jié)論·············································································22參考文獻·······································································23綜述胃底腺息肉
6、的研究進展··················································26致謝···················································································38個人簡歷·············································································39中文摘要200例胃底腺息肉臨床病理特征分析摘要胃底腺息肉
7、是指胃底胃體黏膜形成的單發(fā)或多發(fā)性廣基息肉樣隆起，現(xiàn)已是胃息肉的常見組織學(xué)類型。WHO推出的消化系統(tǒng)腫瘤分類最新版本中，將胃息肉從廣義上分為腫瘤性息肉和非腫瘤性息肉兩大類。胃內(nèi)腫瘤性息肉病變包括呈息肉樣外觀的癌、神經(jīng)內(nèi)分泌腫瘤、腺瘤性息肉（腸型）、胃型腺瘤（幽門腺腺瘤和小凹型腺瘤）以及胃底腺息肉(fundicglandpolyps，F(xiàn)GPs)。其他息肉病變?nèi)缭錾韵⑷?、錯構(gòu)瘤性息肉以及其它具有息肉樣生長方式的病變等均歸類為非腫瘤性病變。胃底腺息肉雖歸類于腫瘤性息肉，但一般被認(rèn)為是良性病變，臨床常多發(fā)。目前
8、胃底腺息肉發(fā)病機制不清，臨床缺乏規(guī)范診治指南。既往認(rèn)為家族性腺瘤性息肉病(familialadenomatouspolyposis，F(xiàn)AP)常合并FGPs，其癌變風(fēng)險很高。但近年報道無FAP的患者亦發(fā)生FGPs。FAP患者多合并腺瘤息肉病桿菌(APC)及其下游目標(biāo)靶向基因β-連接素基因的突變。β-連接素是Wnt信號轉(zhuǎn)導(dǎo)通路中致癌的關(guān)鍵分子，可激活下游靶基因CyclinD1的轉(zhuǎn)錄，引起細(xì)胞增殖和分化失控，導(dǎo)致腫瘤發(fā)生。國內(nèi)關(guān)于非
