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1、PaperRenoprotectiveeffectsoftelmisartaninthe5/6nephrectomisedrats?#§^IchiroTsunenari,*TsuyoshiOhmura,RandolphSeidler,MotohikoChachin,ToshihiroHayashi,￥++?AyakoKonomi,TakehisaMatsumaru,*ToshiyukiSumida,NaoyukiHayashi,YoshiharuHorieKeywords:Abstractpharmacologicalpropertiesoftelmisartan,fibrosis,Thepu
2、rposeofthisstudywastoinvestigatetheclinicalstudieshavebeenconductedtoevaluatevessel,kidney,renoprotectiveeffectoftelmisartanonthetheclinicaleffectivenessandsafetyoftelmisartanangiotensin,advancedstagesofnephropathyinratswithondiabeticnephropathyinpatientswithtype2TGF-β5/6nephrectomy(5/6Nx).Telmisart
3、anwasorallydiabetes.Ithasbeenreportedthattelmisartan*Pharmacokineticsandadministeredfor12weekstoratsthatpreviouslyarrestedprogressiverenaldysfunctioninNon-ClinicalSafetyunderwent5/6Nxorshamoperations.Afterhypertensivepatientswithearly-stagediabeticDepartment,Kawanishicompletionoftheadministrationper
4、iod,thenephropathy.7Makinoetal.8reportedthePharmaResearchInstitute,NippondegreeofrenalinjurywasexaminedeffectivenessofthisdrugtherapyinsuppressingBoehringerIngelheimhistopathologicallyusingindicesoftheprogressionofnephropathyintype2diabeticCo.,Ltd.,3-10-1Yato,Kawanishi,Japan.glomerulosclerosisandles
5、ionsoftherenaltubulepatientswithorwithouthypertension,withoutandinterstitium.Animmunohistochemicalserioussafetyconcerns.RemuzziandRemuzzi9?ProjectCoordinationreviewedthepotentialprotectiveeffectsofstainingfortransforminggrowthfactor–betaGroup,KawanishiPharmaResearch(TGF-β1)wasalsoperformed.telmisart
6、anonrenalfunctiondeteriorationandInstitute,NipponThesuppressionofurinaryproteinwassuggestedthattelmisartanmayeffectivelyBoehringerIngelheimstatisticallysignificantinsurvivinganimalsdosedamelioraterenaldysfunctioninpatientsaffectedCo.,Ltd.,3-10-1Yato,Kawanishi,Japan.withtelmisartan.Theenalaprilgroup’
7、surinarybythemetabolicsyndrome.Inaddition,proteinwasalsosignificantlysuppressedfortelmisartanalsoshowedrenoprotectiveeffectsin#Corporatethesesameparametersinsurvivinganimals.someanimalmodels:spontaneo
