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7、濟南250014)〔摘要〕目的觀察首烏益智靈對血管性癡呆(VD)模型大鼠腦組織SOD活性、MDA含量的影響,并探討其對血管性癡呆的干預(yù)機理。方法用改良Pulsinelli四血管阻斷(42VO)法制造血管性癡呆大鼠模型,設(shè)首烏益智靈組、腦復(fù)康組、模型組、假手術(shù)組,分別測定干預(yù)后各組大鼠腦組織中的超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量。結(jié)果灌胃20d后,首烏益智靈組大鼠腦組織中的SOD活性顯著提高、MDA含量顯著降低,與模型組和腦復(fù)康組相比有顯著差異(P<0105,P<0101)。結(jié)論首烏益智靈具有提高VD大鼠腦組織中的SOD活性
